Current state of the art MRI for the longitudinal assessment of cystic fibrosis

JC Woods, JM Wild, MO Wielpütz… - Journal of Magnetic …, 2020 - Wiley Online Library
Pulmonary MRI can now provide high‐resolution images that are sensitive to early disease
and specific to inflammation in cystic fibrosis (CF) lung disease. With specificity and function …

[HTML][HTML] In vivo methods and applications of xenon-129 magnetic resonance

H Marshall, NJ Stewart, HF Chan, M Rao… - Progress in Nuclear …, 2021 - Elsevier
Hyperpolarised gas lung MRI using xenon-129 can provide detailed 3D images of the
ventilated lung airspaces, and can be applied to quantify lung microstructure and detailed …

Expanding applications of pulmonary MRI in the clinical evaluation of lung disorders: Fleischner Society position paper

H Hatabu, Y Ohno, WB Gefter, G Parraga, B Madore… - Radiology, 2020 - pubs.rsna.org
Pulmonary MRI provides structural and quantitative functional images of the lungs without
ionizing radiation, but it has had limited clinical use due to low signal intensity from the lung …

Protocols for multi‐site trials using hyperpolarized 129Xe MRI for imaging of ventilation, alveolar‐airspace size, and gas exchange: A position paper from the 129Xe …

PJ Niedbalski, CS Hall, M Castro… - Magnetic resonance …, 2021 - Wiley Online Library
Hyperpolarized (HP) 129Xe MRI uniquely images pulmonary ventilation, gas exchange, and
terminal airway morphology rapidly and safely, providing novel information not possible …

Lung MRI with hyperpolarised gases: current & future clinical perspectives

NJ Stewart, LJ Smith, HF Chan… - The British Journal of …, 2022 - academic.oup.com
The use of pulmonary MRI in a clinical setting has historically been limited. Whilst CT
remains the gold-standard for structural lung imaging in many clinical indications, technical …

Using hyperpolarized 129Xe gas-exchange MRI to model the regional airspace, membrane, and capillary contributions to diffusing capacity

Z Wang, L Rankine, EA Bier… - Journal of Applied …, 2021 - journals.physiology.org
Hyperpolarized 129Xe MRI has emerged as a novel means to evaluate pulmonary function
via 3D mapping of ventilation, interstitial barrier uptake, and RBC transfer. However, the …

Quantitative imaging metrics for the assessment of pulmonary pathophysiology: an official American Thoracic Society and Fleischner Society joint workshop report

CCW Hsia, JHT Bates, B Driehuys, SB Fain… - Annals of the …, 2023 - atsjournals.org
Multiple thoracic imaging modalities have been developed to link structure to function in the
diagnosis and monitoring of lung disease. Volumetric computed tomography (CT) renders …

Large-scale investigation of deep learning approaches for ventilated lung segmentation using multi-nuclear hyperpolarized gas MRI

JR Astley, AM Biancardi, PJC Hughes, H Marshall… - Scientific Reports, 2022 - nature.com
Respiratory diseases are leading causes of mortality and morbidity worldwide. Pulmonary
imaging is an essential component of the diagnosis, treatment planning, monitoring, and …

Quantification of pulmonary functional MRI: state-of-the-art and emerging image processing methods and measurements

M Sharma, PV Wyszkiewicz… - Physics in Medicine …, 2022 - iopscience.iop.org
Pulmonary functional magnetic resonance imaging (PfMRI) provides a way to non-invasively
map and measure the spatial distribution of pulmonary ventilation, perfusion and gas …

The assessment of short-and long-term changes in lung function in cystic fibrosis using 129Xe MRI

LJ Smith, A Horsley, J Bray, PJC Hughes… - European …, 2020 - Eur Respiratory Soc
Introduction Xenon-129 (129Xe) ventilation magnetic resonance imaging (MRI) is sensitive
to detect early cystic fibrosis (CF) lung disease and response to treatment. 129Xe-MRI could …