Neonatal hypoxia ischaemia: mechanisms, models, and therapeutic challenges
LJ Millar, L Shi, A Hoerder-Suabedissen… - Frontiers in cellular …, 2017 - frontiersin.org
Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …
human neonates, and is often associated with persistent motor, sensory, and cognitive …
Acid-sensing ion channels in pain and disease
Why do neurons sense extracellular acid? In large part, this question has driven increasing
investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous …
investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous …
Mild hypercapnia or normocapnia after out-of-hospital cardiac arrest
Background Guidelines recommend normocapnia for adults with coma who are resuscitated
after out-of-hospital cardiac arrest. However, mild hypercapnia increases cerebral blood flow …
after out-of-hospital cardiac arrest. However, mild hypercapnia increases cerebral blood flow …
The therapeutic importance of acid-base balance
BN Quade, MD Parker, R Occhipinti - Biochemical pharmacology, 2021 - Elsevier
Baking soda and vinegar have been used as home remedies for generations and today we
are only a mouse-click away from claims that baking soda, lemon juice, and apple cider …
are only a mouse-click away from claims that baking soda, lemon juice, and apple cider …
Targeting two different levels of both arterial carbon dioxide and arterial oxygen after cardiac arrest and resuscitation: a randomised pilot trial
P Jakkula, M Reinikainen, J Hästbacka, P Loisa… - Intensive care …, 2018 - Springer
Purpose We assessed the effects of targeting low-normal or high-normal arterial carbon
dioxide tension (PaCO 2) and normoxia or moderate hyperoxia after out-of-hospital cardiac …
dioxide tension (PaCO 2) and normoxia or moderate hyperoxia after out-of-hospital cardiac …
Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments
In cortical and hippocampal neurons, cation-chloride cotransporters (CCCs) control the
reversal potential (EGABA) of GABAA receptor-mediated current and voltage responses …
reversal potential (EGABA) of GABAA receptor-mediated current and voltage responses …
Ion dynamics during seizures
JV Raimondo, RJ Burman, AA Katz… - Frontiers in cellular …, 2015 - frontiersin.org
Changes in membrane voltage brought about by ion fluxes through voltage and transmitter-
gated channels represent the basis of neural activity. As such, electrochemical gradients …
gated channels represent the basis of neural activity. As such, electrochemical gradients …
[图书][B] Carbonic anhydrase: mechanism, regulation, links to disease, and industrial applications
The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic
anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by …
anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by …
Arterial carbon dioxide tension and outcome in patients admitted to the intensive care unit after cardiac arrest
BACKGROUND: Arterial carbon dioxide tension (PaCO2) affects neuronal function and
cerebral blood flow. However, its association with outcome in patients admitted to intensive …
cerebral blood flow. However, its association with outcome in patients admitted to intensive …
Targeted therapeutic mild hypercapnia after cardiac arrest: a phase II multi-centre randomised controlled trial (the CCC trial)
GM Eastwood, AG Schneider, S Suzuki, L Peck… - Resuscitation, 2016 - Elsevier
Background In intensive care observational studies, hypercapnia after cardiac arrest (CA) is
independently associated with improved neurological outcome. However, the safety and …
independently associated with improved neurological outcome. However, the safety and …