Respiratory infections are a leading cause of mortality worldwide. Most of the research on
the underlying disease mechanisms is based on cell culture, organoid, or surrogate animal …

Macrophages participate to the first line of defense against infectious agents. Microbial
pathogens evolved sophisticated mechanisms to escape macrophage killing. Here, we …

The leading cause of many respiratory diseases is an ongoing and progressive
inflammatory response. Traditionally, inflammatory lung diseases were studied primarily …

Lung disorders such as chronic obstructive pulmonary disease (COPD) and lower
respiratory tract infections (LRTIs) are leading causes of death in humans globally. Cigarette …

The Gram-negative bacterium Yersinia pestis causes plague, a fatal flea-borne
anthropozoonosis, which can progress to aerosol-transmitted pneumonia. Y. pestis …

The SARS-CoV-2 outbreak focused global attention on the shortcomings of the drug
discovery process. It led to its acceleration in several areas, particularly in the processes …

Respiratory disease is a leading cause of mortality in patients with osteogenesis imperfecta
(OI), a connective tissue disease that causes severely reduced bone mass and is most …

Early after inhalation, Yersinia pestis replicates to high numbers in the airways in the
absence of disease symptoms or notable inflammatory responses to cause primary …

Coxiella burnetii is a highly infectious pathogen that causes Q fever, a leading cause of
culture-negative endocarditis. Coxiella first targets alveolar macrophages and forms a …

The human pulmonary environment is complex, containing a matrix of cells, including
fibroblasts, epithelial cells, interstitial macrophages, alveolar macrophages and neutrophils …