Living cells continually generate reactive oxygen species (ROS) through the respiratory
chain during energetic metabolism. ROS at low or moderate concentration can play …

Reactive oxygen species (ROS) are induced through a variety of endogenous and
exogenous sources. Overwhelming of antioxidant and DNA repair mechanisms in the cell by …

Caloric restriction (CR) extends the life span and health span of a variety of species and
slows the progression of age-related hearing loss (AHL), a common age-related disorder …

Similar to many other biological molecules, RNA is vulnerable to chemical insults from
endogenous and exogenous sources. Noxious agents such as reactive oxygen species or …

Overproduction of free radicals can damage cellular components resulting in progressive
physiological dysfunction, which has been implicated in many human diseases. Oxidative …

Despite the long held hypothesis that oxidant stress results in accumulated oxidative
damage to cellular macromolecules and subsequently to aging and age-related chronic …

Age-related hearing loss (AHL), known as presbycusis, is a universal feature of mammalian
aging and is the most common sensory disorder in the elderly population. The molecular …

Caloric restriction has consistently been shown to extend life span and ameliorate aging-
related diseases. These effects may be due to diet-induced reactive oxygen species acting …

Intracellular levels of reactive oxygen species (ROS) increase as a consequence of
oxidative stress and represent a major source of damage to biomolecules. Due to its high …

Damage to RNA from ultraviolet light, oxidation, chlorination, nitration, and akylation can
include chemical modifications to nucleobases as well as RNA-RNA and RNA-protein …