Unconventional insulins from predators and pathogens
SH Laugesen, DHC Chou… - Nature Chemical Biology, 2022 - nature.com
Insulin and its related peptides are found throughout the animal kingdom, in which they
serve diverse functions. This includes regulation of glucose homeostasis, neuronal …
serve diverse functions. This includes regulation of glucose homeostasis, neuronal …
A previously unrecognized superfamily of macro-conotoxins includes an inhibitor of the sensory neuron calcium channel Cav2. 3
CM Hackney, P Flórez Salcedo, E Mueller, TL Koch… - PLoS …, 2023 - journals.plos.org
Animal venom peptides represent valuable compounds for biomedical exploration. The
venoms of marine cone snails constitute a particularly rich source of peptide toxins, known …
venoms of marine cone snails constitute a particularly rich source of peptide toxins, known …
[PDF][PDF] Reconstructing the origins of the somatostatin and allatostatin-C signaling systems using the accelerated evolution of biodiverse cone snail toxins
TL Koch, IBL Ramiro, P Flórez Salcedo… - Molecular Biology …, 2022 - academic.oup.com
Somatostatin and its related peptides (SSRPs) form an important family of hormones with
diverse physiological roles. The ubiquitous presence of SSRPs in vertebrates and several …
diverse physiological roles. The ubiquitous presence of SSRPs in vertebrates and several …
Conotoxin contulakin-G engages a neurotensin receptor 2/R-type calcium channel (Cav2. 3) pathway to mediate spinal antinociception
Intrathecal application of contulakin-G (CGX), a conotoxin peptide and a neurotensin
analogue, has been demonstrated to be safe and potentially analgesic in humans. However …
analogue, has been demonstrated to be safe and potentially analgesic in humans. However …
A toxin-based approach to neuropeptide and peptide hormone discovery
Peptide hormones and neuropeptides form a diverse class of bioactive secreted molecules
that control essential processes in animals. Despite breakthroughs in peptide discovery …
that control essential processes in animals. Despite breakthroughs in peptide discovery …
Characterization of an Aplysia vasotocin signaling system and actions of posttranslational modifications and individual residues of the ligand on receptor activity
JP Xu, XY Ding, SQ Guo, HY Wang, WJ Liu… - Frontiers in …, 2023 - frontiersin.org
The vasopressin/oxytocin signaling system is present in both protostomes and
deuterostomes and plays various physiological roles. Although there were reports for both …
deuterostomes and plays various physiological roles. Although there were reports for both …
Partial sciatic nerve ligation: a mouse model of chronic neuropathic pain to study the antinociceptive effect of novel therapies
HE Korah, K Cheng, SM Washington… - JoVE (Journal of …, 2022 - jove.com
Management of chronic pain remains challenging to this day, and current treatments are
associated with adverse effects, including tolerance and addiction. Chronic neuropathic pain …
associated with adverse effects, including tolerance and addiction. Chronic neuropathic pain …
Characterisation of Elevenin-Vc1 from the Venom of Conus victoriae: A Structural Analogue of α-Conotoxins
Elevenins are peptides found in a range of organisms, including arthropods, annelids,
nematodes, and molluscs. They consist of 17 to 19 amino acid residues with a single …
nematodes, and molluscs. They consist of 17 to 19 amino acid residues with a single …
[HTML][HTML] Discovery and development of macrocyclic peptide modulators of the cannabinoid 2 receptor
N Tomašević, FS Emser, E Muratspahić… - Journal of Biological …, 2024 - Elsevier
The cannabinoid type 2 receptor (CB 2 R), a G protein–coupled receptor, is an important
regulator of immune cell function and a promising target to treat chronic inflammation and …
regulator of immune cell function and a promising target to treat chronic inflammation and …
[HTML][HTML] Proteomic analysis of the venom of Conus flavidus from Red Sea reveals potential pharmacological applications
MO Germoush, M Fouda, H Aly, I Saber… - Journal of Genetic …, 2024 - Elsevier
Background Venomous marine cone snails produce unique neurotoxins called
conopeptides or conotoxins, which are valuable for research and drug discovery …
conopeptides or conotoxins, which are valuable for research and drug discovery …