The large number of ion channels found in all nervous systems poses fundamental
questions concerning how the characteristic intrinsic properties of single neurons are …

Due to its complex and multifaceted nature, developing effective treatments for epilepsy is
still a major challenge. To deal with this complexity we introduce the concept of degeneracy …

The notions of degeneracy and redundancy are important constructs in many areas, ranging
from genomics through to network science. Degeneracy finds a powerful role in …

A fundamental question in neuroscience is whether neuronal circuits with variable circuit
parameters that produce similar outputs respond comparably to equivalent perturbations. 1 …

Internal state alters sensory behaviors to optimize survival strategies. The neuronal
mechanisms underlying hunger-dependent behavioral plasticity are not fully characterized …

It is difficult to answer important questions in neuroscience, such as:“how do neural circuits
generate behaviour?,” because research is limited by the complexity and inaccessibility of …

Neurons regulate their excitability by adjusting their ion channel levels. Degeneracy–
achieving equivalent outcomes (excitability) using different solutions (channel combinations) …

A heterogeneous neuronal population in the suprachiasmatic nucleus (SCN) sustains a cell-
autonomous code for circadian time, implemented by firing-rate plasticity involving multiple …

Hunger state can substantially alter the perceived value of a stimulus, even to the extent that
the same sensory cue can trigger antagonistic behaviors. How the nervous system uses …

The amygdala contributes to multiple functions including attention allocation, sensory
processing, decision-making, and the elaboration of emotional behaviors. The diversity of …