It has been known for a long time that thyroid hormones have prominent effects on hepatic
fatty acid and cholesterol synthesis and metabolism. Indeed, hypothyroidism has been …

Background: Thyroid hormones (THs) exert a strong influence on mammalian lipid
metabolism at the systemic and hepatic levels by virtue of their roles in regulating circulating …

The nongenomic actions of thyroid hormone begin at receptors in the plasma membrane,
mitochondria or cytoplasm. These receptors can share structural homologies with nuclear …

Thyroid dysfunction, manifesting as either overt or subclinical hypothyroidism, negatively
affects lipid metabolism: this leads to hypercholesterolemia which progressively increases …

Nonalcoholic fatty liver disease (NAFLD) is a worldwide rising challenge because of hepatic,
but also extrahepatic, complications. Thyroid hormones are master regulators of energy and …

Classically, medical textbooks taught that most effects of thyroid hormones (THs) on energy
homeostasis are directly exerted in peripheral tissues. However, current evidence is …

Obesity is associated with insulin resistance and type 2 diabetes; molecular mechanisms
that promote energy expenditure can be utilized for effective therapy. Src-associated in …

Background Mitochondria are dynamic organelles that frequently undergo fission and fusion
processes, and imbalances in these processes may be involved in obesity and insulin …

Publisher Summary This chapter reviews the recent advancements in the study of the
transport and metabolism of thyroid hormone. It discusses the role of deiodination …

Since the realization that the cellular homologs of a gene found in the retrovirus that
contributes to erythroblastosis in birds (v-erbA), ie the proto-oncogene c-erbA encodes the …