The Ruminant Telomere-to-Telomere (RT2T) Consortium
Abstract Telomere-to-telomere (T2T) assemblies reveal new insights into the structure and
function of the previously 'invisible'parts of the genome and allow comparative analyses of …
function of the previously 'invisible'parts of the genome and allow comparative analyses of …
Phylogenomics and the genetic architecture of the placental mammal radiation
The genomes of placental mammals are being sequenced at an unprecedented rate.
Alignments of hundreds, and one day thousands, of genomes spanning the rich living and …
Alignments of hundreds, and one day thousands, of genomes spanning the rich living and …
Single-haplotype comparative genomics provides insights into lineage-specific structural variation during cat evolution
The role of structurally dynamic genomic regions in speciation is poorly understood due to
challenges inherent in diploid genome assembly. Here we reconstructed the evolutionary …
challenges inherent in diploid genome assembly. Here we reconstructed the evolutionary …
Assembly of a pangenome for global cattle reveals missing sequences and novel structural variations, providing new insights into their diversity and evolutionary …
Y Zhou, L Yang, X Han, J Han, Y Hu, F Li… - Genome …, 2022 - genome.cshlp.org
A cattle pangenome representation was created based on the genome sequences of 898
cattle representing 57 breeds. The pangenome identified 83 Mb of sequence not found in …
cattle representing 57 breeds. The pangenome identified 83 Mb of sequence not found in …
Long read genome assemblies complemented by single cell RNA-sequencing reveal genetic and cellular mechanisms underlying the adaptive evolution of yak
X Gao, S Wang, YF Wang, S Li, SX Wu, RG Yan… - Nature …, 2022 - nature.com
Wild yak (Bos mutus) and domestic yak (Bos grunniens) are adapted to high altitude
environment and have ecological, economic, and cultural significances on the Qinghai …
environment and have ecological, economic, and cultural significances on the Qinghai …
False gene and chromosome losses in genome assemblies caused by GC content variation and repeats
Background Many short-read genome assemblies have been found to be incomplete and
contain mis-assemblies. The Vertebrate Genomes Project has been producing new …
contain mis-assemblies. The Vertebrate Genomes Project has been producing new …
Novel functional sequences uncovered through a bovine multiassembly graph
Many genomic analyses start by aligning sequencing reads to a linear reference genome.
However, linear reference genomes are imperfect, lacking millions of bases of unknown …
However, linear reference genomes are imperfect, lacking millions of bases of unknown …
Structural variant-based pangenome construction has low sensitivity to variability of haplotype-resolved bovine assemblies
Advantages of pangenomes over linear reference assemblies for genome research have
recently been established. However, potential effects of sequence platform and assembly …
recently been established. However, potential effects of sequence platform and assembly …
Graph construction method impacts variation representation and analyses in a bovine super-pangenome
Background Several models and algorithms have been proposed to build pangenomes from
multiple input assemblies, but their impact on variant representation, and consequently …
multiple input assemblies, but their impact on variant representation, and consequently …
The Bovine Pangenome Consortium: democratizing production and accessibility of genome assemblies for global cattle breeds and other bovine species
Abstract The Bovine Pangenome Consortium (BPC) is an international collaboration
dedicated to the assembly of cattle genomes to develop a more complete representation of …
dedicated to the assembly of cattle genomes to develop a more complete representation of …