Diabetic neuropathy is a common complication of both type 1 and type 2 diabetes, which
affects over 90% of the diabetic patients. Although pain is one of the main symptoms of …

This review summarizes evidence, primarily from recent human studies, indirectly supporting
a novel hypothesis: that the assessment of healthy individuals' responses to standardized …

Both myelinated and unmyelinated afferents are implicated in transmitting diabetic
neuropathic pain. Although unmyelinated afferents are generally considered to play a …

Peripheral neuropathy, and specifically distal peripheral neuropathy (DPN), is one of the
most frequent and troublesome complications of diabetes mellitus. It is the major reason for …

Myocardial ischaemia causes the release of metabolites such as bradykinin, which
stimulates cardiac sensory receptors to evoke a sympathoexcitatory reflex. However, the …

Background: Streptozotocin (STZ) is used as a common tool to induce diabetes and to study
diabetes-induced complications including diabetic peripheral neuropathy (DPN). Previously …

J. Neurochem.(2010) 114, 1460–1475. Abstract Abnormal hyperexcitability of primary
sensory neurons plays an important role in neuropathic pain. Voltage‐gated potassium (Kv) …

Aims/hypothesis Sensory neuropathy in diabetic patients frequently presents itself as
progressive loss of thermal perception, while some patients describe concurrent …

We investigated antinociceptive activity of botulinum toxin type A (BTX-A) in a model of
diabetic neuropathic pain in rats. Male Wistar rats were made diabetic by a single …

Peripheral nerve injury increases spontaneous action potential discharge in spinal dorsal
horn neurons and augments their response to peripheral stimulation. This “central …