Tropomyosins are rodlike coiled coil dimers that form continuous polymers along the major
groove of most actin filaments. In striated muscle, tropomyosin regulates the actin-myosin …

Endothelium forms a semi-permeable barrier that separates blood from the underlying
tissue. Barrier function is largely determined by cell-cell and cell-matrix adhesions that …

Trafficking between membrane compartments is a characteristic of eukaryotic cells and
relies on transport carriers that bud and fission from a donor membrane, before being …

Actin filament functional diversity is paralleled by variation in the composition of isoforms of
tropomyosin in these filaments. Although the role of tropomyosin is well understood in …

Opioids are among the most effective analgesics available and are the first choice in the
treatment of acute severe pain. However, partial efficacy, a tendency to produce tolerance …

The paradox of how the Golgi and other organelles can sort a continuous flux of protein and
lipid but maintain temporal and morphological stability remains unresolved. Recent …

The specific functions of greater than 40 vertebrate nonmuscle tropomyosins (Tms) are
poorly understood. In this article we have tested the ability of two Tm isoforms, TmBr3 and …

Activated macrophages secrete an array of proinflammatory cytokines, including tumor
necrosis factor-α (TNFα) and interleukin 6 (IL-6), that are temporally secreted for sequential …

In skeletal muscle and adipose tissue, insulin-stimulated glucose uptake is dependent upon
translocation of the insulin-responsive glucose transporter GLUT4 from intracellular storage …

Although the actin cytoskeleton is widely believed to play an important role in intracellular
protein transport, this role is poorly understood. Recently, progress has been made toward …