Circulating tumor cells (CTCs) are the seeds of distant metastasis, and the number of CTCs
detected in the blood of cancer patients is associated with a worse prognosis. CTCs face …

Bone and the immune system are both complex tissues that respectively regulate the
skeleton and the body's response to invading pathogens. It has now become clear that these …

Megakaryocytes (MKs) are responsible for platelet biogenesis, which is believed to occur
canonically in adult bone marrow (BM) and in the fetal liver during development. However …

Craniofacial bone defects can result from various disorders, including congenital
malformations, tumor resection, infection, severe trauma, and accidents. Successfully …

The seemingly unqualified reliance and near-universal dependence upon in vivo dual-
energy X-ray absorptiometric (DXA) methodology to provide accurate, quantitative, and …

Megakaryocytes associate with the bone marrow vasculature where they convert their
cytoplasm into proplatelets that protrude through the vascular endothelium into the lumen …

We report transplanted hemopoietic stem cells (HSC) preferentially lodge within two cells of
mature megakaryocytes (MM). With both populations comprising~ 0.2% of bone marrow …

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by increased
bleeding tendency and thrombocytopenia. In fact, the precise pathogenesis of this disease is …

Megakaryocytes are rare cells found in the bone marrow, responsible for the everyday
production and release of millions of platelets into the bloodstream. Since the discovery and …

The bone represents surprisingly dynamic structures that are subject to constant remodeling
by the concerted action of bone-forming osteoblasts and bone-resorbing osteoclasts-two cell …