Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

Amino acids are basic nutrients for immune cells during organ development, tissue
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …

Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Methionine uptake and metabolism is involved in a host of cellular functions including
methylation reactions, redox maintenance, polyamine synthesis and coupling to folate …

BACKGROUND Reduced caloric intake without malnutrition is the oldest known life span–
extending intervention. Laboratory studies throughout the 20th century established and …

Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …

Consuming a Mediterranean diet rich in minimally processed plant foods has been
associated with a reduced risk of developing multiple chronic diseases and increased life …

Life on Earth emerged in a hydrogen sulfide (H 2 S)-rich environment eons ago and with it
protein persulfidation mediated by H 2 S evolved as a signaling mechanism. Protein …

Cysteine hydropersulfide (CysSSH) occurs in abundant quantities in various organisms, yet
little is known about its biosynthesis and physiological functions. Extensive persulfide …

Several metabolic alterations accumulate over time along with a reduction in biological
fitness, suggesting the existence of a" metabolic clock" that controls aging. Multiple inborn …