Pioneer transcription factors have the intrinsic biochemical ability to scan partial DNA
sequence motifs that are exposed on the surface of a nucleosome and thus access silent …

Transmitter signalling is the universal chemical language of any nervous system, but little is
known about its early evolution. Here, we summarize data about the distribution and …

INTRODUCTION The ability to regenerate tissues lost to damage or disease is widely but
nonuniformly distributed in vertebrates. Some animals such as teleost fishes can regenerate …

Regeneration is the process by which organisms replace lost or damaged tissue, and
regenerative capacity can vary greatly among species, tissues and life stages. Tissue …

The cranial neural crest generates a huge diversity of derivatives, including the bulk of
connective and skeletal tissues of the vertebrate head. How neural crest cells acquire such …

Rationale: The adult human heart is an organ with low regenerative potential. Heart failure
following acute myocardial infarction is a leading cause of death due to the inability of …

For successful regeneration, the identity of the missing tissue must be specified according to
the pre-existing tissue. Planarians are ideal for the study of the mechanisms underlying this …

Regeneration is a heroic biological process that restores tissue architecture and function in
the face of day-to-day cell loss or the aftershock of injury. Capacities and mechanisms for …

Background: Acute kidney injury (AKI) is associated with damage to the nephrons and
tubular epithelial cells (TECs), which can lead to chronic kidney disease and end-stage …

Many highly regenerative organisms maintain adult pluripotent stem cells throughout their
life, but how the long-term maintenance of pluripotency is accomplished is unclear. To …