Introduction The enhanced permeability and retention (EPR) effect serves as the foundation
of anticancer nanomedicine design. EPR effect-based drug delivery is an effective strategy …

Recently, numerous polymer materials have been employed as drug carrier systems in
medicinal research, and their detailed properties have been thoroughly evaluated. Water …

Abstract Design, controlled synthesis, physico-chemical and biological characteristics of
novel well-defined biodegradable star-shaped copolymers intended for advanced drug …

The study compared the physico-chemical and biological properties of a water-soluble star-
like polymer nanomedicine with three micellar nanomedicines formed by self-assembly of …

Abstract N-(2-hydroxypropyl) methacrylamide-based block copolymers (pHPMA) have
received attention due to their hydrophilicity, non-immunogenicity, biocompatibility and …

The extracellular matrix (ECM) is dynamically involved in many aspects of cell growth and
survival, and it plays an active role in cancer etiology. In comparison to healthy ECM, tumor …

Highlights•HPMA (N-2-hydroxypropylmethacrylamide) is an emerging polymeric alternative
for drug delivery applications.•HPMA can be potentially conjugated to develop copolymers …

Inflammation is a vital defense mechanism of living organisms. However, persistent and
chronic inflammation may lead to severe pathological processes and evolve into various …

Biodegradable polymer-based therapeutics have recently become essential drug delivery
biomaterials for various bioactive compounds. Biodegradable and biocompatible polymer …

We developed a new simplified method for the synthesis of well-defined linear, diblock, or
starlike N-(2-hydroxypropyl) methacrylamide (HPMA)-based polymer drug carriers using …