Causal mapping of human brain function
Mapping human brain function is a long-standing goal of neuroscience that promises to
inform the development of new treatments for brain disorders. Early maps of human brain …
inform the development of new treatments for brain disorders. Early maps of human brain …
The future of brain circuit-targeted therapeutics
The principle of targeting brain circuits has drawn increasing attention with the growth of
brain stimulation treatments such as transcranial magnetic stimulation (TMS), deep brain …
brain stimulation treatments such as transcranial magnetic stimulation (TMS), deep brain …
[HTML][HTML] Lead-DBS v3. 0: Mapping deep brain stimulation effects to local anatomy and global networks
Following its introduction in 2014 and with support of a broad international community, the
open-source toolbox Lead-DBS has evolved into a comprehensive neuroimaging platform …
open-source toolbox Lead-DBS has evolved into a comprehensive neuroimaging platform …
Therapies to restore consciousness in patients with severe brain injuries: a gap analysis and future directions
Abstract Background/Objective For patients with disorders of consciousness (DoC) and their
families, the search for new therapies has been a source of hope and frustration. Almost all …
families, the search for new therapies has been a source of hope and frustration. Almost all …
Probabilistic mapping of deep brain stimulation: insights from 15 years of therapy
Deep brain stimulation (DBS) depends on precise delivery of electrical current to target
tissues. However, the specific brain structures responsible for best outcome are still debated …
tissues. However, the specific brain structures responsible for best outcome are still debated …
A neural network for tics: insights from causal brain lesions and deep brain stimulation
Brain lesions are a rare cause of tic disorders. However, they can provide uniquely causal
insights into tic pathophysiology and can also inform on possible neuromodulatory …
insights into tic pathophysiology and can also inform on possible neuromodulatory …
[HTML][HTML] Deep brain stimulation: Imaging on a group level
Abstract Deep Brain Stimulation (DBS) is an established treatment option for movement
disorders and is under investigation for treatment in a growing number of other brain …
disorders and is under investigation for treatment in a growing number of other brain …
A unified functional network target for deep brain stimulation in obsessive-compulsive disorder
Background Multiple deep brain stimulation (DBS) targets have been proposed for treating
intractable obsessive-compulsive disorder (OCD). Here, we investigated whether stimulation …
intractable obsessive-compulsive disorder (OCD). Here, we investigated whether stimulation …
Patient‐specific structural connectivity informs outcomes of responsive neurostimulation for temporal lobe epilepsy
Objective Responsive neurostimulation is an effective therapy for patients with refractory
mesial temporal lobe epilepsy. However, clinical outcomes are variable, few patients …
mesial temporal lobe epilepsy. However, clinical outcomes are variable, few patients …
Subthalamic and pallidal deep brain stimulation: are we modulating the same network?
The subthalamic nucleus and internal pallidum are main target sites for deep brain
stimulation in Parkinson's disease. Multiple trials that investigated subthalamic versus …
stimulation in Parkinson's disease. Multiple trials that investigated subthalamic versus …