Systematic review of the therapeutic role of apoptotic inhibitors in neurodegeneration and their potential use in schizophrenia

C Morén, N Treder, A Martínez-Pinteño, N Rodríguez… - Antioxidants, 2022 - mdpi.com
Schizophrenia (SZ) is a deleterious brain disorder affecting cognition, emotion and reality
perception. The most widely accepted neurochemical-hypothesis is the imbalance of …

Hormone targets for the treatment of sleep disorders in postmenopausal women with schizophrenia: a narrative review

A González-Rodríguez, J Haba-Rubio, J Usall… - Clocks & Sleep, 2022 - mdpi.com
While the early identification of insomnia in patients with schizophrenia is of clinical
relevance, the use of specific compounds to treat insomnia has been studied less in …

Investigation of the protective effect of resveratrol in an MK-801-induced mouse model of schizophrenia

MS Akosman, R Türkmen, HH Demirel - Environmental Science and …, 2021 - Springer
Increasing evidence supports the view that oxidative stress and brain demyelination play an
important role in the pathogenesis of schizophrenia. Resveratrol is a powerful antioxidant …

Inflammatory, synaptic, motor, and behavioral alterations induced by gestational sepsis on the offspring at different stages of life

MG Granja, LP Alves, M Leardini-Tristão… - Journal of …, 2021 - Springer
Background The term sepsis is used to designate a systemic condition of infection and
inflammation associated with hemodynamic changes that result in organic dysfunction …

Effect of add-on ramelteon therapy on sleep and circadian rhythm disruption in patients with schizophrenia: A randomized controlled trial

A Mishra, R Maiti, BR Mishra, M Jena, S Nath… - European …, 2020 - Elsevier
The sleep and circadian rhythm disruptions in schizophrenia are attributed to a decrease in
nocturnal melatonin level which may worsen if treated with conventional sedative drugs …

NMDA glutamate receptor antagonist MK‐801 induces proteome changes in adult human brain slices which are partially counteracted by haloperidol and clozapine

V de Almeida, ND Mendes, GS Zuccoli… - Journal of …, 2024 - Wiley Online Library
Deciphering the molecular pathways associated with N‐methyl‐D‐aspartate receptor
(NMDAr) hypofunction and its interaction with antipsychotics is necessary to advance our …

Melatonin attenuates scopolamine‐induced cognitive dysfunction through SIRT1/IRE1α/XBP1 pathway

XQ Liu, S Huang, JY Zheng, C Wan… - CNS Neuroscience …, 2024 - Wiley Online Library
Background The prevalence of dementia around the world is increasing, and these patients
are more likely to have cognitive impairments, mood and anxiety disorders (depression …

Pharmacotherapy and emerging treatment strategies for schizophrenia

JK Sinha, P Sachdeva, F Ahmad, J Sarkar… - … of Schizophrenia:: A …, 2023 - Springer
Schizophrenia (ScZ) is a mental condition in which individuals' views of reality are distorted.
Hallucinations, delusions, altered cognition, and behavior are some of the symptoms of ScZ …

Modulation of neural circuits by melatonin in neurodegenerative and neuropsychiatric disorders

A Giri, S Mehan, Z Khan, G Das Gupta… - Naunyn-Schmiedeberg's …, 2024 - Springer
Neurodegenerative and neuropsychiatric disorders are two broad categories of neurological
disorders characterized by progressive impairments in movement and cognitive functions …

[HTML][HTML] Evaluating the Effect of Melatonin on Positive and Negative Symptoms of Schizophrenic Patients: A Randomized Placebo-Controlled Study

F Behrouzian, L Abdi, M Nazarinasab… - Iranian Journal of …, 2023 - ncbi.nlm.nih.gov
Objective: Schizophrenia is known as a severe psychiatric disorder with a broad range of
clinical indications and symptoms such as positive and negative symptoms. This study was …