Perioperative metformin treatment to reduce postoperative hyperglycemia after colon cancer surgery: a randomized clinical trial

EPC Tauby, RD Bojesen, C Grube… - Diseases of the Colon …, 2024 - journals.lww.com
BACKGROUND: Surgery induces a stress response, causing insulin resistance that may
result in postoperative hyperglycemia, which is associated with increased incidence of …

Identification of clinical and pharmacogenetic factors influencing metformin response in Type 2 diabetes mellitus

N Pérez-Gómez, MD Fernández-Ortega… - …, 2023 - Taylor & Francis
Metformin, a hypoglycemic drug for Type 2 diabetes mellitus, shows variability in
pharmacokinetics and response due to membrane transporters. This study followed 34 Type …

[HTML][HTML] Multi-Omics Analysis Revealed the rSNPs Potentially Involved in T2DM Pathogenic Mechanism and Metformin Response

IS Damarov, EE Korbolina, EY Rykova… - International Journal of …, 2024 - mdpi.com
The goal of our study was to identify and assess the functionally significant SNPs with
potentially important roles in the development of type 2 diabetes mellitus (T2DM) and/or their …

Atomistic description of the OCTN1 recognition mechanism via in silico methods

O Ben Mariem, L Palazzolo, B Torre, Y Wei, D Bianchi… - Plos one, 2024 - journals.plos.org
The Organic Cation Transporter Novel 1 (OCTN1), also known as SLC22A4, is widely
expressed in various human tissues, and involved in numerous physiological and …

Osteoking prevents bone loss and enhances osteoblastic bone formation by modulating the AGEs/IGF‐1/β‐catenin/OPG pathway in type 2 diabetic db/db mice

Y Yang, R Li, P Wang, Y Zhao, J Li… - Cell Biology …, 2024 - Wiley Online Library
Type 2 diabetic osteoporosis (T2DOP) is a skeletal metabolic syndrome characterized by
impaired bone remodeling due to type 2 diabetes mellitus, and there are drawbacks in the …

Cross-disease modeling of peripheral blood identifies biomarkers of type 2 diabetes predictive of Alzheimer's disease

BK Ball, JH Park, EA Proctor, DK Brubaker - bioRxiv, 2024 - biorxiv.org
Type 2 diabetes (T2D) is a significant risk factor for Alzheimer's disease (AD). Despite
multiple studies reporting this connection, the mechanism by which T2D exacerbates AD is …

Leveraging Machine Learning to Identify Synergistic Drug Combinations for Effective Cancer Treatment

P Sujatha, K Saravanan, MA Sohail… - … on Image Information …, 2023 - ieeexplore.ieee.org
The potential of drug combinations to treat and overcome medication resistance complex
genetic diseases is evident. Synergistic drug combinations offer a promising way to enhance …

The Glucoregulatory Mechanisms, Pharmacokinetics and Pharmacogenetics of Metformin in Type 2 Diabetes Mellitus

H Naesa, D Joujeh - Journal of Advanced Pharmacy Research, 2024 - journals.ekb.eg
Background and Objective: Type 2 diabetes (T2D) is a common chronic disease affecting
more than 420 million people worldwide. Metformin, a biguanide drug that lowers blood …

Hubungan Persepsi Penyakit dan Durasi Menderita terhadap Manajemen Perawatan Diri pada Penderita Diabetes Mellitus: The Relationship of Disease Perception …

BF Krisdianto, H Malini, S Zuela - Ners Jurnal Keperawatan, 2024 - ners.fkep.unand.ac.id
Manajemen perawatan diri sangat penting untuk mencegah komplikasi pada individu
dengan diabetes mellitus, yang dipengaruhi oleh berbagai faktor, termasuk persepsi …

Genetic and Epigenetic Factors Influencing Population Variability of Allele-Specific Expression

MP Harwood - 2023 - search.proquest.com
There is a longstanding investigation in human genetics surrounding how individuals with
the same genotype display highly variable phenotypes. The impact of gene expression …