Perioperative metformin treatment to reduce postoperative hyperglycemia after colon cancer surgery: a randomized clinical trial
EPC Tauby, RD Bojesen, C Grube… - Diseases of the Colon …, 2024 - journals.lww.com
BACKGROUND: Surgery induces a stress response, causing insulin resistance that may
result in postoperative hyperglycemia, which is associated with increased incidence of …
result in postoperative hyperglycemia, which is associated with increased incidence of …
Identification of clinical and pharmacogenetic factors influencing metformin response in Type 2 diabetes mellitus
N Pérez-Gómez, MD Fernández-Ortega… - …, 2023 - Taylor & Francis
Metformin, a hypoglycemic drug for Type 2 diabetes mellitus, shows variability in
pharmacokinetics and response due to membrane transporters. This study followed 34 Type …
pharmacokinetics and response due to membrane transporters. This study followed 34 Type …
[HTML][HTML] Multi-Omics Analysis Revealed the rSNPs Potentially Involved in T2DM Pathogenic Mechanism and Metformin Response
IS Damarov, EE Korbolina, EY Rykova… - International Journal of …, 2024 - mdpi.com
The goal of our study was to identify and assess the functionally significant SNPs with
potentially important roles in the development of type 2 diabetes mellitus (T2DM) and/or their …
potentially important roles in the development of type 2 diabetes mellitus (T2DM) and/or their …
Atomistic description of the OCTN1 recognition mechanism via in silico methods
O Ben Mariem, L Palazzolo, B Torre, Y Wei, D Bianchi… - Plos one, 2024 - journals.plos.org
The Organic Cation Transporter Novel 1 (OCTN1), also known as SLC22A4, is widely
expressed in various human tissues, and involved in numerous physiological and …
expressed in various human tissues, and involved in numerous physiological and …
Osteoking prevents bone loss and enhances osteoblastic bone formation by modulating the AGEs/IGF‐1/β‐catenin/OPG pathway in type 2 diabetic db/db mice
Y Yang, R Li, P Wang, Y Zhao, J Li… - Cell Biology …, 2024 - Wiley Online Library
Type 2 diabetic osteoporosis (T2DOP) is a skeletal metabolic syndrome characterized by
impaired bone remodeling due to type 2 diabetes mellitus, and there are drawbacks in the …
impaired bone remodeling due to type 2 diabetes mellitus, and there are drawbacks in the …
Cross-disease modeling of peripheral blood identifies biomarkers of type 2 diabetes predictive of Alzheimer's disease
Type 2 diabetes (T2D) is a significant risk factor for Alzheimer's disease (AD). Despite
multiple studies reporting this connection, the mechanism by which T2D exacerbates AD is …
multiple studies reporting this connection, the mechanism by which T2D exacerbates AD is …
Leveraging Machine Learning to Identify Synergistic Drug Combinations for Effective Cancer Treatment
The potential of drug combinations to treat and overcome medication resistance complex
genetic diseases is evident. Synergistic drug combinations offer a promising way to enhance …
genetic diseases is evident. Synergistic drug combinations offer a promising way to enhance …
The Glucoregulatory Mechanisms, Pharmacokinetics and Pharmacogenetics of Metformin in Type 2 Diabetes Mellitus
H Naesa, D Joujeh - Journal of Advanced Pharmacy Research, 2024 - journals.ekb.eg
Background and Objective: Type 2 diabetes (T2D) is a common chronic disease affecting
more than 420 million people worldwide. Metformin, a biguanide drug that lowers blood …
more than 420 million people worldwide. Metformin, a biguanide drug that lowers blood …
Hubungan Persepsi Penyakit dan Durasi Menderita terhadap Manajemen Perawatan Diri pada Penderita Diabetes Mellitus: The Relationship of Disease Perception …
BF Krisdianto, H Malini, S Zuela - Ners Jurnal Keperawatan, 2024 - ners.fkep.unand.ac.id
Manajemen perawatan diri sangat penting untuk mencegah komplikasi pada individu
dengan diabetes mellitus, yang dipengaruhi oleh berbagai faktor, termasuk persepsi …
dengan diabetes mellitus, yang dipengaruhi oleh berbagai faktor, termasuk persepsi …
Genetic and Epigenetic Factors Influencing Population Variability of Allele-Specific Expression
MP Harwood - 2023 - search.proquest.com
There is a longstanding investigation in human genetics surrounding how individuals with
the same genotype display highly variable phenotypes. The impact of gene expression …
the same genotype display highly variable phenotypes. The impact of gene expression …