Fibrosis of the diabetic heart: Clinical significance, molecular mechanisms, and therapeutic opportunities

I Tuleta, NG Frangogiannis - Advanced drug delivery reviews, 2021 - Elsevier
In patients with diabetes, myocardial fibrosis may contribute to the pathogenesis of heart
failure and arrhythmogenesis, increasing ventricular stiffness and delaying conduction …

[HTML][HTML] Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy

ZV Varga, Z Giricz, L Liaudet, G Haskó… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Diabetes is a recognized risk factor for cardiovascular diseases and heart failure. Diabetic
cardiovascular dysfunction also underscores the development of diabetic retinopathy …

[HTML][HTML] Ursolic acid ameliorates oxidative stress, inflammation and fibrosis in diabetic cardiomyopathy rats

X Wang, Y Gong, B Zhou, J Yang, Y Cheng… - Biomedicine & …, 2018 - Elsevier
Diabetic cardiomyopathy is a major and severe cardiovascular complication of diabetes
mellitus. Ursolic acid, a pentacyclic triterpene compound widespread in fruits and plants …

Impact of inflammation and anti-inflammatory modalities on diabetic cardiomyopathy healing: from fundamental research to therapy

XJ Zhang, XW Han, YH Jiang, YL Wang, XL He… - International …, 2023 - Elsevier
Diabetic cardiomyopathy (DCM) is a prevalent cardiovascular complication of diabetes
mellitus, characterized by high morbidity and mortality rates worldwide. However, treatment …

Nobiletin attenuates cardiac dysfunction, oxidative stress, and inflammatory in streptozotocin: induced diabetic cardiomyopathy

N Zhang, Z Yang, SZ Xiang, YG Jin, WY Wei… - Molecular and cellular …, 2016 - Springer
Diabetic cardiomyopathy, characterized by the presence of diastolic and/or systolic
myocardial dysfunction, is one of the major causes of heart failure. Nobiletin, which is …

Intermedin protects against myocardial ischemia-reperfusion injury in diabetic rats

H Li, Y Bian, N Zhang, J Guo, C Wang, WB Lau… - Cardiovascular …, 2013 - Springer
Background Diabetic patients, through incompletely understood mechanisms, endure
exacerbated ischemic heart injury compared to non-diabetic patients. Intermedin (IMD) is a …

Isosteviol ameliorates diabetic cardiomyopathy in rats by inhibiting ERK and NF-κB signaling pathways

SG Tang, XY Liu, JM Ye, TT Hu… - Journal of …, 2018 - joe.bioscientifica.com
Diabetes-induced injury of myocardium, defined as diabetic cardiomyopathy (DCM),
accounts for significant mortality and morbidity in diabetic population. Alleviation of DCM by …

Insulin replacement limits progression of diabetic cardiomyopathy in the low-dose streptozotocin-induced diabetic rat

M Tate, M Deo, AH Cao, SG Hood… - Diabetes and …, 2017 - journals.sagepub.com
Diabetic cardiomyopathy is a major contributor to the increasing burden of heart failure
globally. Effective therapies remain elusive, in part due to the incomplete understanding of …

Anti-inflammatory, anti-oxidant and anti-apoptotic effects of olive leaf extract in cardiac tissue of diabetic rats

AA Asghari, M Mahmoudabady… - Journal of Pharmacy …, 2022 - academic.oup.com
Objectives Inflammatory process and apoptosis are involved in the pathogenesis of cardiac
injury and oxidative damage caused by diabetes mellitus. The cardioprotective effects of …

Urolithins at physiological concentrations affect the levels of pro-inflammatory cytokines and growth factor in cultured cardiac cells in hyperglucidic conditions

R Sala, P Mena, M Savi, F Brighenti, A Crozier… - Journal of Functional …, 2015 - Elsevier
Diabetic cardiomyopathy (DCM) develops independently of common cardiovascular co-
morbidities and is initiated by the metabolic derangements accompanying diabetes mellitus …