Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells
Pluripotent stem cells (PSCs) represent an alternative hematopoietic stem cell (HSC) source
for treating hematopoietic disease. The limited engraftment of human PSC–derived (hPSC …
for treating hematopoietic disease. The limited engraftment of human PSC–derived (hPSC …
A multidrug-resistant engineered CAR T cell for allogeneic combination immunotherapy
J Valton, V Guyot, A Marechal, JM Filhol, A Juillerat… - Molecular Therapy, 2015 - cell.com
The adoptive transfer of chimeric antigen receptor (CAR) T cell represents a highly
promising strategy to fight against multiple cancers. The clinical outcome of such therapies is …
promising strategy to fight against multiple cancers. The clinical outcome of such therapies is …
Efficient enrichment of gene-modified primary T cells via CCR5-targeted integration of mutant dihydrofolate reductase
B Paul, GSR Ibarra, N Hubbard, T Einhaus… - … Therapy-Methods & …, 2018 - cell.com
Targeted gene therapy strategies utilizing homology-driven repair (HDR) allow for greater
control over transgene integration site, copy number, and expression—significant …
control over transgene integration site, copy number, and expression—significant …
Clinical Trials Using LV-P140K-MGMT for Gliomas
Y Lin, SL Gerson - Gene Therapy of Cancer, 2014 - Elsevier
The field of gene therapy has experienced some success in the past decade. However,
overall, gene therapy clinical trials have been challenging due to low transduction efficiency …
overall, gene therapy clinical trials have been challenging due to low transduction efficiency …
Selectively weakened binding of methotrexate by human dihydrofolate reductase allows rapid ex vivo selection of mammalian cells
JP Volpato, N Mayotte, E Fossati… - Journal of Molecular …, 2011 - Wiley Online Library
Ex vivo selection of transduced hematopoietic stem cells (HSC) with drug‐resistance genes
offers the possibility to enrich transduced cells prior to engraftment, toward increased …
offers the possibility to enrich transduced cells prior to engraftment, toward increased …
In vivo protection of activated Tyr22‐dihydrofolate reductase gene‐modified canine T lymphocytes from methotrexate
JL Gori, BC Beard, NP Williams… - The journal of gene …, 2013 - Wiley Online Library
Background Nonmyeloablative allogeneic hematopoietic stem cell (HSC) transplantation
can cure malignant and nonmalignant diseases affecting the hematopoietic system, such as …
can cure malignant and nonmalignant diseases affecting the hematopoietic system, such as …
Methotrexate supports in vivo selection of human embryonic stem cell derived-hematopoietic cells expressing dihydrofolate reductase
Human embryonic stem cells (hESCs) are an attractive alternative cell source for
hematopoietic gene therapy applications as the cells are easily modified with lentiviral or …
hematopoietic gene therapy applications as the cells are easily modified with lentiviral or …
The induction of mixed chimerism using ES cell-derived hematopoietic stem cells
F Milanetti, YH Cheng, RK Burt - The Immunological Barriers to …, 2012 - Springer
The use of haematopoietic stem cell (HSC) transplantation for the establishment of mixed
chimerism generally leads to durable immune tolerance to allografts in animal models of …
chimerism generally leads to durable immune tolerance to allografts in animal models of …