Pathophysiology of Inflammatory Bowel Diseases Research on IBDs has identified disrupted
immune responses in the gastrointestinal mucosa and putative disruptions in the gut …

Among human leukocyte antigen (HLA)-associated disorders, celiac disease has an
immunopathogenesis that is particularly well understood. The condition is characterized by …

Checkpoint blockade with antibodies specific for the PD-1 and CTLA-4 inhibitory receptors
can induce durable responses in a wide range of human cancers. However, the …

Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …

Foxp3‐expressing regulatory T (Treg) cells, which are indispensable for preventing
autoimmunity, also suppress effective tumor immunity. Treg cells abundantly infiltrate into …

Regulatory T (Treg) cells expressing the transcription factor Foxp3 have a critical role in the
maintenance of immune homeostasis and prevention of autoimmunity. Recent advances in …

Systematic interrogation of tumor-infiltrating lymphocytes is key to the development of
immunotherapies and the prediction of their clinical responses in cancers. Here, we perform …

The success of immunotherapy in oncology underscores the vital role of the immune system
in cancer development. Regulatory T cells (Tregs) maintain a fine balance between …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

Multiple sclerosis (MS) is a common degenerative disorder of the central nervous system.
The decreased frequency and dysfunction of Treg cells cause inflammation and disease …