Topoisomerases are ubiquitous enzymes that control DNA supercoiling and entanglements.
They are essential during transcription and replication, and topoisomerase inhibitors are …

Abstract PI3K/AKT signaling leads to reduced apoptosis, stimulates cell growth and
increases proliferation. Under normal conditions, PI3K/AKT activation is tightly controlled …

Only a fraction of patients with metastatic colorectal cancer receive clinical benefit from
therapy with anti-epidermal growth factor receptor (EGFR) antibodies, which calls for the …

Both genetic and epigenetic changes contribute to development of human cancer.
Oncogenomics has primarily focused on understanding the genetic basis of neoplasia, with …

Background: In metastatic colorectal cancer (mCRC), KRAS is the only validated biomarker
used to select patients for administration of epidermal growth factor receptor (EGFR) …

The plasmacytoma variant translocation 1 (PVT1) is a long non-coding RNA gene involved
in human disease, mainly in cancer onset/progression. Although widely analysed, its …

Colorectal cancer (CRC) is the third most common cancer in the USA. MicroRNAs play
important roles in the pathogenesis of CRC. In this study, we investigated the role of miR …

Mucinous carcinomas are uncommon histological types that affect several organ sites.
Primary mucinous carcinomas of the ovary are distinct from other ovarian carcinoma types …

Altered gut microbiota and a damaged colon mucosal barrier have been implicated in the
development of colon cancer. Astragalus mongholicus Bunge-Curcuma aromatica …

Reversible acetylation of histone and nonhistone proteins plays pivotal role in cellular
homeostasis. Dysfunction of histone acetyltransferases (HATs) leads to several diseases …