Targeting circular RNAs as a therapeutic approach: current strategies and challenges
Significant progress has been made in circular RNA (circRNA) research in recent years.
Increasing evidence suggests that circRNAs play important roles in many cellular processes …
Increasing evidence suggests that circRNAs play important roles in many cellular processes …
Circular RNA: An emerging frontier in RNA therapeutic targets, RNA therapeutics, and mRNA vaccines
Circular RNAs (circRNA) is a class of natural (biogenic) or synthetic closed RNA without 5′
or 3′ ends. Meanwhile, their unique covalently-closed structures of circRNA prevent RNA …
or 3′ ends. Meanwhile, their unique covalently-closed structures of circRNA prevent RNA …
N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non …
Z Liu, T Wang, Y She, K Wu, S Gu, L Li, C Dong… - Molecular cancer, 2021 - Springer
Background An in-depth understanding of immune evasion mechanisms in tumors is crucial
to overcome resistance and enable innovative advances in immunotherapy. Circular RNAs …
to overcome resistance and enable innovative advances in immunotherapy. Circular RNAs …
Translation and functional roles of circular RNAs in human cancer
M Lei, G Zheng, Q Ning, J Zheng, D Dong - Molecular cancer, 2020 - Springer
Circular RNAs (circRNAs) are a new class of non-coding RNAs formed by covalently closed
loops through backsplicing. Recent methodologies have enabled in-depth characterization …
loops through backsplicing. Recent methodologies have enabled in-depth characterization …
Circular RNAs in cancer: biogenesis, function, and clinical significance
J Li, D Sun, W Pu, J Wang, Y Peng - Trends in cancer, 2020 - cell.com
Circular RNA (circRNA) is a class of single-stranded molecules with tissue/development-
specific expression patterns. Unlike linear RNA, circRNA forms a covalently closed loop …
specific expression patterns. Unlike linear RNA, circRNA forms a covalently closed loop …
[HTML][HTML] Review on circular RNAs and new insights into their roles in cancer
X Tang, H Ren, M Guo, J Qian, Y Yang, C Gu - … and structural biotechnology …, 2021 - Elsevier
Circular RNAs (circRNAs) are a very interesting class of conserved single-stranded RNA
molecules derived from exonic or intronic sequences by precursor mRNA back-splicing …
molecules derived from exonic or intronic sequences by precursor mRNA back-splicing …
[HTML][HTML] WNT/β-catenin signaling in the development of liver cancers
S He, S Tang - Biomedicine & pharmacotherapy, 2020 - Elsevier
The WNT/β-catenin signaling pathway is a highly conserved and tightly controlled molecular
mechanism that regulates embryonic development, cellular proliferation and differentiation …
mechanism that regulates embryonic development, cellular proliferation and differentiation …
Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA
P Wu, Y Mo, M Peng, T Tang, Y Zhong, X Deng… - Molecular cancer, 2020 - Springer
Non-coding RNAs do not encode proteins and regulate various oncological processes. They
are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics …
are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics …
The functional roles of the circRNA/Wnt axis in cancer
CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of
species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt …
species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt …
Circ3823 contributes to growth, metastasis and angiogenesis of colorectal cancer: involvement of miR-30c-5p/TCF7 axis
Y Guo, Y Guo, C Chen, D Fan, X Wu, L Zhao, B Shao… - Molecular cancer, 2021 - Springer
Background Colorectal cancer (CRC) is one of the most common malignant tumours. The
recurrence and metastasis of CRC seriously affect the survival rate of patients. Angiogenesis …
recurrence and metastasis of CRC seriously affect the survival rate of patients. Angiogenesis …