Introducing neurofilament light chain measure in psychiatry: current evidence, opportunities, and pitfalls
The recent introduction of new-generation immunoassay methods allows the reliable
quantification of structural brain markers in peripheral matrices. Neurofilament light chain …
quantification of structural brain markers in peripheral matrices. Neurofilament light chain …
The 2022 lady estelle wolfson lectureship on neurofilaments
A Petzold - Journal of neurochemistry, 2022 - Wiley Online Library
Neurofilament proteins (Nf) have been validated and established as a reliable body fluid
biomarker for neurodegenerative pathology. This review covers seven Nf isoforms, Nf light …
biomarker for neurodegenerative pathology. This review covers seven Nf isoforms, Nf light …
Association between retinal features from multimodal imaging and schizophrenia
Importance The potential association of schizophrenia with distinct retinal changes is of
clinical interest but has been challenging to investigate because of a lack of sufficiently large …
clinical interest but has been challenging to investigate because of a lack of sufficiently large …
The physio-affective phenome of major depression is strongly associated with biomarkers of astroglial and neuronal projection toxicity which in turn are associated …
HK Al-Hakeim, TH Al-Naqeeb, AF Almulla… - Journal of affective …, 2023 - Elsevier
Background Major depressive disorder (MDD) is characterized by elevated activity of
peripheral neuro-immune and neuro-oxidative pathways, which may cause neuro-affective …
peripheral neuro-immune and neuro-oxidative pathways, which may cause neuro-affective …
Plasma neurofilament light in behavioural variant frontotemporal dementia compared to mood and psychotic disorders
Objective: Blood biomarkers of neuronal injury such as neurofilament light (NfL) show
promise to improve diagnosis of neurodegenerative disorders and distinguish …
promise to improve diagnosis of neurodegenerative disorders and distinguish …
Exploring new mechanism of depression from the effects of virus on nerve cells
X Yu, S Wang, W Wu, H Chang, P Shan, L Yang… - Cells, 2023 - mdpi.com
Depression is a common neuropsychiatric disorder with long-term recurrent depressed
mood, pain and despair, pessimism and anxiety, and even suicidal tendencies as the main …
mood, pain and despair, pessimism and anxiety, and even suicidal tendencies as the main …
Neurofilaments–Small proteins of physiological significance and predictive power for future neurodegeneration and cognitive decline across the life span
Neurofilaments (NFs) are not only important for axonal integrity and nerve conduction in
large myelinated axons but they are also thought to be crucial for receptor and synaptic …
large myelinated axons but they are also thought to be crucial for receptor and synaptic …
Comorbidity of ketamine dependence with major depressive disorder increases the vulnerability to neuroaxonal pathology
MC Huang, CH Chen, TH Liu, AN Chung, YL Liu… - Journal of psychiatric …, 2023 - Elsevier
We recently demonstrated that patients with ketamine dependence (KD) have increased
serum levels of neurofilament light chain (NfL), a novel marker of active neuroaxonal …
serum levels of neurofilament light chain (NfL), a novel marker of active neuroaxonal …
Plasma neurofilament light chain in association to late‐life depression in the general population
Aim Investigating what is underlying late‐life depression is becoming increasingly important
with the rapidly growing elderly population. Yet, the associations between plasma …
with the rapidly growing elderly population. Yet, the associations between plasma …
Neurodegeneration markers in the cerebrospinal fluid of 100 patients with schizophrenia spectrum disorder
K Runge, A Balla, BL Fiebich, SJ Maier… - Schizophrenia …, 2023 - academic.oup.com
Background Schizophrenia spectrum disorders (SSD) can be associated with
neurodegenerative processes causing disruption of neuronal, synaptic, or axonal integrity …
neurodegenerative processes causing disruption of neuronal, synaptic, or axonal integrity …