Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans

CO Eleazu, KC Eleazu, S Chukwuma… - Journal of diabetes & …, 2013 - Springer
Abstract Streptozotocin (STZ)(2-deoxy-2-({[methyl (nitroso) amino] carbonyl} amino)-β-D-
glucopyranose) is a naturally occurring diabetogenic compound, produced by the soil …

Management of benign prostatic hyperplasia: could dietary polyphenols be an alternative to existing therapies?

C Eleazu, K Eleazu, W Kalu - Frontiers in pharmacology, 2017 - frontiersin.org
The incidence of benign prostatic hyperplasia (BPH) is gradually on the increase. While
conventional drugs such as the α1-adrenergic receptor antagonists and 5α-reductase …

Salivary molecular spectroscopy: A sustainable, rapid and non-invasive monitoring tool for diabetes mellitus during insulin treatment

DC Caixeta, EMG Aguiar, L Cardoso-Sousa… - PLoS …, 2020 - journals.plos.org
Monitoring of blood glucose is an invasive, painful and costly practice in diabetes.
Consequently, the search for a more cost-effective (reagent-free), non-invasive and specific …

Antidiabetic and Antihyperlipidemic Activities of the Leaf Latex Extract of Aloe megalacantha Baker (Aloaceae) in Streptozotocin‐Induced Diabetic Model

WW Hammeso, YK Emiru… - Evidence‐Based …, 2019 - Wiley Online Library
Background. Diabetes mellitus has become a major public health and economic problem
across the globe. The inadequacies, as well as serious adverse effects associated with …

Evaluation of in vivo antidiabetic, antidyslipidemic, and in vitro antioxidant activities of hydromethanolic root extract of Datura stramonium L. (Solanaceae)

YM Belayneh, Z Birhanu, EM Birru… - Journal of experimental …, 2019 - Taylor & Francis
Background The global morbidity and mortality rates of diabetes mellitus are persistently
increasing. There is a demand for new antidiabetic drugs because the safety and efficacy of …

Comparative effects of incretin-based therapy on doxorubicin-induced nephrotoxicity in rats: the role of SIRT1/Nrf2/NF-κB/TNF-α signaling pathways

SR Botros, AI Matouk, A Amin, GH Heeba - Frontiers in Pharmacology, 2024 - frontiersin.org
Introduction: Nephrotoxicity represents a major complication of using doxorubicin (DOX) in
the management of several types of cancers. Increased oxidative stress and the activation of …

Antidiabetic properties of phytosynthesized gold nanoparticles (AuNPs) from Datura stramonium seed

IC Oladipo, A Lateef, MA Azeez, TB Asafa… - IOP conference …, 2020 - iopscience.iop.org
The gold nanoparticles synthesized from Datura stramonium seed was investigated for its
antidiabetic properties in the present study. A total number of 42 healthy male albino rats …

Antioxidant, antidiabetic and hypolipidemic effects of Tulbaghia violacea Harv. (wild garlic) rhizome methanolic extract in a diabetic rat model

K Moodley, K Joseph, Y Naidoo, S Islam… - BMC complementary and …, 2015 - Springer
Background The prevalence of diabetes mellitus (DM) continues to rise alarmingly despite
years of intensive research. The need to explore alternative remedies such as traditional …

Silymarin reduces retinal microvascular damage in streptozotocin-induced diabetic rats

R Karimi, A Bakhshi, P Dayati, O Abazari, M Shahidi… - Scientific Reports, 2022 - nature.com
Diabetic retinopathy is a severe microvascular problem in diabetes mellitus. Silymarin is a
flavonoid compound, and according to previous studies, it is a bioactive compound with …

Protective effect of empagliflozin on gentamicin-induced acute renal injury via regulation of SIRT1/NF-κB signaling pathway

SR Botros, AI Matouk, A Anter, MMA Khalifa… - Environmental …, 2022 - Elsevier
Gentamicin is a highly effective antibiotic. However, its major complication is nephrotoxicity.
This study investigated the beneficial effects of empagliflozin against gentamicin-induced …