Fluorine in anti-HIV drugs approved by FDA from 1981 to 2023
S Han, Y Lu - European Journal of Medicinal Chemistry, 2023 - Elsevier
Human immunodeficiency virus (HIV) is the etiological agent of acquired immunodeficiency
syndrome (AIDS). Nowadays, FDA has approved over thirty antiretroviral drugs grouped in …
syndrome (AIDS). Nowadays, FDA has approved over thirty antiretroviral drugs grouped in …
“Big Three” infectious diseases: tuberculosis, malaria and HIV/AIDS
P Makam, R Matsa - Current Topics in Medicinal Chemistry, 2021 - ingentaconnect.com
Infectious diseases have been evolving and re-evolving over the ages and causing
immense misery to humans. Among them, some have been prevented and eradicated, but …
immense misery to humans. Among them, some have been prevented and eradicated, but …
Predicted effects of the introduction of long-acting injectable cabotegravir pre-exposure prophylaxis in sub-Saharan Africa: a modelling study
Background Long-acting injectable cabotegravir pre-exposure prophylaxis (PrEP) is
recommended by WHO as an additional option for HIV prevention in sub-Saharan Africa, but …
recommended by WHO as an additional option for HIV prevention in sub-Saharan Africa, but …
Current ART, determinants for virologic failure and implications for HIV drug resistance: an umbrella review
Objective The purpose of this study is to investigate the incidence of determinants for
virologic failure and to identify predisposing factors to enhance treatment efficacy. Tackling …
virologic failure and to identify predisposing factors to enhance treatment efficacy. Tackling …
Associations of modern initial antiretroviral therapy regimens with all-cause mortality in people living with HIV in resource-limited settings: a retrospective multicenter …
X Wu, G Wu, P Ma, R Wang, L Li, Y Chen, J Xu… - Nature …, 2023 - nature.com
Despite the proven virological advantages, there remains some controversy regarding
whether first-line integrase strand transfer inhibitors (INSTIs)-based antiretroviral therapy …
whether first-line integrase strand transfer inhibitors (INSTIs)-based antiretroviral therapy …
Cabotegravir/Rilpivirine: the last FDA-approved drug to treat HIV
Introduction The development of long-acting (LA) drugs has changed the management of
common medical conditions for human replication immunodeficiency virus (HIV). Cabenuva …
common medical conditions for human replication immunodeficiency virus (HIV). Cabenuva …
Current ARTs, virologic failure, and implications for AIDS management: a systematic review
FET Foka, HT Mufhandu - Viruses, 2023 - mdpi.com
Antiretroviral therapies (ARTs) have revolutionized the management of human
immunodeficiency virus (HIV) infection, significantly improved patient outcomes, and …
immunodeficiency virus (HIV) infection, significantly improved patient outcomes, and …
The latest FDA-approved pharmaceuticals containing fragments of tailor-made amino acids and fluorine
Nowadays, the selective introduction of fluorine into bioactive compounds is a mature
strategy in the design of drugs allowing to increase efficiency, biological half-life and bio …
strategy in the design of drugs allowing to increase efficiency, biological half-life and bio …
[HTML][HTML] Switching to coformulated bictegravir, emtricitabine, and tenofovir alafenamide maintained viral suppression in adults with historical virological failures and …
MS Tsai, HY Sun, CP Chen, CH Lee, CY Lee… - International Journal of …, 2023 - Elsevier
Objectives Real-world experience with coformulated bictegravir, emtricitabine, and tenofovir
alafenamide (BIC/FTC/TAF) is sparse as a switch regimen among people living with HIV …
alafenamide (BIC/FTC/TAF) is sparse as a switch regimen among people living with HIV …
Therapeutic Potential and Predictive Pharmaceutical Modeling of Stilbenes in Cannabis sativa
C O'Croinin, A Garcia Guerra, MR Doschak… - Pharmaceutics, 2023 - mdpi.com
Cannabis sativa is a plant used for recreational and therapeutic purposes; however, many of
the secondary metabolites in the plant have not been thoroughly investigated. Stilbenes are …
the secondary metabolites in the plant have not been thoroughly investigated. Stilbenes are …