Fluorine in anti-HIV drugs approved by FDA from 1981 to 2023

S Han, Y Lu - European Journal of Medicinal Chemistry, 2023 - Elsevier
Human immunodeficiency virus (HIV) is the etiological agent of acquired immunodeficiency
syndrome (AIDS). Nowadays, FDA has approved over thirty antiretroviral drugs grouped in …

“Big Three” infectious diseases: tuberculosis, malaria and HIV/AIDS

P Makam, R Matsa - Current Topics in Medicinal Chemistry, 2021 - ingentaconnect.com
Infectious diseases have been evolving and re-evolving over the ages and causing
immense misery to humans. Among them, some have been prevented and eradicated, but …

Predicted effects of the introduction of long-acting injectable cabotegravir pre-exposure prophylaxis in sub-Saharan Africa: a modelling study

J Smith, L Bansi-Matharu, V Cambiano, D Dimitrov… - The Lancet …, 2023 - thelancet.com
Background Long-acting injectable cabotegravir pre-exposure prophylaxis (PrEP) is
recommended by WHO as an additional option for HIV prevention in sub-Saharan Africa, but …

Current ART, determinants for virologic failure and implications for HIV drug resistance: an umbrella review

SA SeyedAlinaghi, AM Afsahi, A Moradi… - AIDS Research and …, 2023 - Springer
Objective The purpose of this study is to investigate the incidence of determinants for
virologic failure and to identify predisposing factors to enhance treatment efficacy. Tackling …

Associations of modern initial antiretroviral therapy regimens with all-cause mortality in people living with HIV in resource-limited settings: a retrospective multicenter …

X Wu, G Wu, P Ma, R Wang, L Li, Y Chen, J Xu… - Nature …, 2023 - nature.com
Despite the proven virological advantages, there remains some controversy regarding
whether first-line integrase strand transfer inhibitors (INSTIs)-based antiretroviral therapy …

Cabotegravir/Rilpivirine: the last FDA-approved drug to treat HIV

E Taki, F Soleimani, A Asadi… - Expert Review of Anti …, 2022 - Taylor & Francis
Introduction The development of long-acting (LA) drugs has changed the management of
common medical conditions for human replication immunodeficiency virus (HIV). Cabenuva …

Current ARTs, virologic failure, and implications for AIDS management: a systematic review

FET Foka, HT Mufhandu - Viruses, 2023 - mdpi.com
Antiretroviral therapies (ARTs) have revolutionized the management of human
immunodeficiency virus (HIV) infection, significantly improved patient outcomes, and …

The latest FDA-approved pharmaceuticals containing fragments of tailor-made amino acids and fluorine

Q Wang, J Han, A Sorochinsky, A Landa, G Butler… - Pharmaceuticals, 2022 - mdpi.com
Nowadays, the selective introduction of fluorine into bioactive compounds is a mature
strategy in the design of drugs allowing to increase efficiency, biological half-life and bio …

[HTML][HTML] Switching to coformulated bictegravir, emtricitabine, and tenofovir alafenamide maintained viral suppression in adults with historical virological failures and …

MS Tsai, HY Sun, CP Chen, CH Lee, CY Lee… - International Journal of …, 2023 - Elsevier
Objectives Real-world experience with coformulated bictegravir, emtricitabine, and tenofovir
alafenamide (BIC/FTC/TAF) is sparse as a switch regimen among people living with HIV …

Therapeutic Potential and Predictive Pharmaceutical Modeling of Stilbenes in Cannabis sativa

C O'Croinin, A Garcia Guerra, MR Doschak… - Pharmaceutics, 2023 - mdpi.com
Cannabis sativa is a plant used for recreational and therapeutic purposes; however, many of
the secondary metabolites in the plant have not been thoroughly investigated. Stilbenes are …