[HTML][HTML] Dual topology of co-chaperones at the membrane of the endoplasmic reticulum
L Daverkausen-Fischer, F Pröls - Cell Death Discovery, 2021 - nature.com
Dual topologies of proteins at the ER membrane are known for a variety of proteins allowing
the same protein to exert different functions according to the topology adopted. A dual …
the same protein to exert different functions according to the topology adopted. A dual …
[HTML][HTML] Hepatocyte-derived lipotoxic extracellular vesicle sphingosine 1-phosphate induces macrophage chemotaxis
Background: The pathophysiology of non-alcoholic steatohepatitis involves hepatocyte
lipotoxicity due to excess saturated free fatty acids and concomitant proinflammatory …
lipotoxicity due to excess saturated free fatty acids and concomitant proinflammatory …
[HTML][HTML] Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a liver tumor that usually arises in patients with cirrhosis.
Hepatic stellate cells are key players in the progression of HCC, as they create a fibrotic …
Hepatic stellate cells are key players in the progression of HCC, as they create a fibrotic …
[HTML][HTML] Hepatic E4BP4 induction promotes lipid accumulation by suppressing AMPK signaling in response to chemical or diet-induced ER stress
Prolonged ER stress has been known to be one of the major drivers of impaired lipid
homeostasis during the pathogenesis of non-alcoholic liver disease (NAFLD). However, the …
homeostasis during the pathogenesis of non-alcoholic liver disease (NAFLD). However, the …
[HTML][HTML] Cache domain containing 1 is a novel marker of non-alcoholic steatohepatitis-associated hepatocarcinogenesis
A Kakehashi, A Chariyakornkul, S Suzuki… - Cancers, 2021 - mdpi.com
Simple Summary The aim of the present study was to discover novel early molecular
biomarkers of liver neoplasms which arise in non-alcoholic steatohepatitis (NASH) Stelic …
biomarkers of liver neoplasms which arise in non-alcoholic steatohepatitis (NASH) Stelic …
Inhibition of eIF2α Dephosphorylation Protects Hepatocytes from Apoptosis by Alleviating ER Stress in Acute Liver Injury
YJ Tang, H Chen, Y Yi, GM Chen… - BioMed research …, 2020 - Wiley Online Library
Objectives. Protein kinase R‐like ER kinase (PERK)/eukaryotic initiation factor 2 alpha
(eIF2α) is an important factor along the main pathways for endoplasmic reticulum (ER) stress …
(eIF2α) is an important factor along the main pathways for endoplasmic reticulum (ER) stress …
Fibroblast growth factor 2 reduces endoplasmic reticulum stress and apoptosis in in-vitro Non-Alcoholic Fatty Liver Disease model
SP Hosseini, S Farivar, R Rezaei, S Tokhanbigli… - DARU Journal of …, 2023 - Springer
Abstract Purpose Non-Alcoholic fatty liver disease is characterized by the accumulation of
excess fat in the liver, chronic inflammation, and cell death, ranging from simple steatosis to …
excess fat in the liver, chronic inflammation, and cell death, ranging from simple steatosis to …
[HTML][HTML] Inhibiting alpha subunit of eukaryotic initiation factor 2 dephosphorylation protects injured hepatocytes and reduces hepatocyte proliferation in acute liver …
G Chen, X Yang, Y He, Y Tang, R Tian… - Croatian Medical …, 2019 - ncbi.nlm.nih.gov
Aim To investigate the impact of alpha subunit of eukaryotic initiation factor 2 (eIF2α)
phosphorylation on liver regeneration. Methods Male BALB/c mice were intraperitoneally …
phosphorylation on liver regeneration. Methods Male BALB/c mice were intraperitoneally …
内质网应激在肝病性别差异形成中的影响及机制.
汪杰， 何毅怀， 陈欢， 龙骏… - Journal of Clinical …, 2019 - search.ebscohost.com
目的探讨内质网应激在肝病性别差异形成中的影响及机制. 方法首先回顾性分析遵义医科大学
附属医院2018 年肝病门诊23 043 例肝病患者及肝病科1110 例肝病患者的性别分布情况; …
附属医院2018 年肝病门诊23 043 例肝病患者及肝病科1110 例肝病患者的性别分布情况; …
Blocking IRE1a;-endoribonuclease activity in hepatic stellate cells decreases tumor cell proliferation and metastasis in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a primary liver tumor that arises in patients with liver
cirrhosis. Activated stellate cells play an essential role in the pathogenesis of HCC. They are …
cirrhosis. Activated stellate cells play an essential role in the pathogenesis of HCC. They are …