Only in recent years, thanks to a precision medicine-based approach, have treatments
tailored to the sex of each patient emerged in clinical trials. In this regard, both striated …

Substantial divergence in cardio-metabolic risk, muscle size, and performance exists
between men and women. Considering the pivotal role of skeletal muscle in human …

Skeletal muscle tissue is in a constant state of turnover, with muscle tissue protein synthesis
and breakdown rates ranging between 1-2% across the day in vivo in humans. Muscle …

Age-related deterioration in turnover of collagen proteins accelerates extracellular matrix
fibrosis and hinders adaptation to external stimuli. This project sought to understand factors …

Metabolic stable isotope labeling with heavy water followed by liquid chromatography
coupled with mass spectrometry (LC-MS) is a powerful tool for in vivo protein turnover …

The rationale for the use of metformin as a treatment to slow aging was largely based on
data collected from metabolically unhealthy individuals. For healthspan extension metformin …

Impaired mitochondrial function and disrupted proteostasis contribute to musculoskeletal
dysfunction. However, few interventions simultaneously target these two drivers to prevent …

Sarcopenia, the progressive loss of muscle mass and function, universally affects older
adults and is closely associated with frailty and reduced quality of life. Despite the inevitable …

Targeting chondrocyte dynamics is a strategy for slowing osteoarthritis progression during
aging. We describe a stable-isotope method using in vivo deuterium oxide labeling and …

High‐fat diet (HFD) and exercise remodel skeletal muscle mitochondria. The electron
transfer flavoproteins (ETF) transfer reducing equivalents from β‐oxidation into the electron …