Increased osteoclast (OC) differentiation and activity is the critical event that results in bone
loss and joint destruction in common pathological bone conditions, such as osteoporosis …

Osteoporosis is a skeletal disorder that causes impairment of bone structure and strength,
leading to a progressively increased risk of fragility fractures. The global prevalence of …

Objective The development of these guidelines is sponsored by the American Association of
Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology …

Osteoporosis is a systemic metabolic bone disease characterized by a reduction in bone
mass, bone quality, and microarchitectural deterioration. An imbalance in bone remodeling …

Background Unlike most chronic diseases, osteoporosis treatments are generally limited to
a single drug at a fixed dose and frequency. Nonetheless, no approved therapy is able to …

ABSTRACT Abbreviations: AACE= American Association of Clinical Endocrinologists AFF=
atypical femur fracture ASBMR= American Society for Bone and Mineral Research BEL …

In the beginning, that is from the 1960's, when a link between menopause and osteoporosis
was first identified; estrogen treatment was the standard for preventing bone loss, however …

Highlights•Parathyroid hormone has dual anabolic and catabolic actions on the
skeleton.•The OPG–RANKL–RANK pathway is the main mediator of the catabolic actions of …

BACKGROUND Disorders of bone metabolism, most notably osteoporosis, are highly
prevalent and predispose to fractures, causing high patient morbidity and mortality …

The past 15 years have witnessed tremendous progress in the molecular understanding of
osteoblasts, the main bone-forming cells in the vertebrate skeleton. In particular, all of the …