Brain tumors across the age spectrum: biology, therapy, and late effects

TE Merchant, IF Pollack, JS Loeffler - Seminars in radiation oncology, 2010 - Elsevier
The clinical difference between brain tumors in adults and children is striking. Compared
with adults, pediatric tumor types (mostly glial and neuronal) are more sensitive to adjuvant …

Medulloblastoma in childhood: new biological advances

JR Crawford, TJ MacDonald, RJ Packer - The Lancet Neurology, 2007 - thelancet.com
Medulloblastoma is the most common embryonal tumour in children. Patients with
medulloblastoma are currently staged as average-risk or poor-risk on the basis of clinical …

Central nervous system cancers

LB Nabors, M Ammirati, PJ Bierman, H Brem… - Journal of the National …, 2013 - jnccn.org
Primary and metastatic tumors of the central nervous system are a heterogeneous group of
neoplasms with varied outcomes and management strategies. Recently, improved survival …

High-risk medulloblastoma: a pediatric oncology group randomized trial of chemotherapy before or after radiation therapy (POG 9031)

NJ Tarbell, H Friedman, WR Polkinghorn… - Journal of clinical …, 2013 - ascopubs.org
Purpose To compare event-free survival (EFS) in children with high-risk medulloblastoma
randomly assigned to receive either chemotherapy before radiation or chemotherapy after …

Management of and prognosis with medulloblastoma: therapy at a crossroads

RJ Packer, G Vezina - Archives of neurology, 2008 - jamanetwork.com
Medulloblastoma is the most common malignant childhood brain tumor and, although
relatively uncommon in older patients, poses a therapeutic challenge in adults. With current …

Classifying the medulloblastoma: insights from morphology and molecular genetics

D Ellison - Neuropathology and applied neurobiology, 2002 - Wiley Online Library
Significant advances in the treatment of the medulloblastoma (MB) have been made in the
last 30 years, reducing mortality by 2‐fold. Further improvements in the cure rate require an …

Medulloblastoma

G Dhall - Journal of child neurology, 2009 - journals.sagepub.com
Medulloblastoma is the most common malignant brain tumor in children. Patients with
medulloblastoma are stratified into ''standard''and ''high''risk categories based on age at …

Clinical and mutational profiles of adult medulloblastoma groups

GCH Wong, KKW Li, WW Wang, APY Liu… - Acta neuropathologica …, 2020 - Springer
Adult medulloblastomas are clinically and molecularly understudied due to their rarity. We
performed molecular grouping, targeted sequencing, and TERT promoter Sanger …

Long‐term results of a prospective study on the treatment of medulloblastoma in adults

AA Brandes, E Franceschi, A Tosoni, V Blatt… - Cancer, 2007 - Wiley Online Library
BACKGROUND. Because medulloblastoma (MB) is rare in adults, the few studies on this
condition have been retrospective, and the follow‐up has tended to be short. Furthermore …

Common strategy for adult and pediatric medulloblastoma: a multicenter series of 253 adults

L Padovani, MP Sunyach, D Perol, C Mercier… - International Journal of …, 2007 - Elsevier
Purpose: To assess prognostic factors for adults with medulloblastoma in a multicenter,
retrospective study. Methods and Materials: Data were collected by file review or mail inquiry …