[HTML][HTML] Tumor-induced inflammatory cytokines and the emerging diagnostic devices for cancer detection and prognosis
Chronic inflammation generated by the tumor microenvironment is known to drive cancer
initiation, proliferation, progression, metastasis, and therapeutic resistance. The tumor …
initiation, proliferation, progression, metastasis, and therapeutic resistance. The tumor …
The multifaceted role of iron in renal health and disease
RPL van Swelm, JFM Wetzels… - Nature Reviews …, 2020 - nature.com
Iron is an essential element that is indispensable for life. The delicate physiological body
iron balance is maintained by both systemic and cellular regulatory mechanisms. The iron …
iron balance is maintained by both systemic and cellular regulatory mechanisms. The iron …
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases
DB Kell - BMC medical genomics, 2009 - Springer
Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …
Hepcidin regulation by innate immune and infectious stimuli
AE Armitage, LA Eddowes, U Gileadi… - Blood, The Journal …, 2011 - ashpublications.org
Hepcidin controls the levels and distribution of iron, an element whose availability can
influence the outcome of infections. We investigated hepcidin regulation by infection …
influence the outcome of infections. We investigated hepcidin regulation by infection …
Regulation of iron metabolism by hepcidin under conditions of inflammation
PJ Schmidt - Journal of Biological Chemistry, 2015 - ASBMB
Iron is a redox-active metal required as a cofactor in multiple metalloproteins essential for a
host of life processes. The metal is highly toxic when present in excess and must be strictly …
host of life processes. The metal is highly toxic when present in excess and must be strictly …
Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli
H Huang, M Constante, A Layoun… - Blood, The Journal of …, 2009 - ashpublications.org
Hepcidin, a key regulator of iron metabolism, is a small antimicrobial peptide produced by
the liver that regulates intestinal iron absorption and iron recycling by macrophages …
the liver that regulates intestinal iron absorption and iron recycling by macrophages …
Hepcidin, the iron watcher
L Viatte, S Vaulont - Biochimie, 2009 - Elsevier
Hepcidin, a peptide hormone produced by the liver, constitutes the master regulator of iron
homeostasis in mammals allowing iron adaptation according to the body iron needs. In …
homeostasis in mammals allowing iron adaptation according to the body iron needs. In …
Current status of the measurement of blood hepcidin levels in chronic kidney disease
IC Macdougall, J Malyszko, RC Hider… - Clinical Journal of the …, 2010 - journals.lww.com
Hepcidin is a small defensin-like peptide produced in the liver in response to anemia,
hypoxia, or inflammation. In addition to its anti-microbial properties, it has also been found to …
hypoxia, or inflammation. In addition to its anti-microbial properties, it has also been found to …
Antimicrobial activity of human hepcidin 20 and 25 against clinically relevant bacterial strains: effect of copper and acidic pH
G Maisetta, R Petruzzelli, FL Brancatisano, S Esin… - Peptides, 2010 - Elsevier
Hepcidin 25 (hep-25) is a peptide primarily produced by human liver with a central role in
iron homeostasis. Its isoform, hepcidin 20 (hep-20), has an unknown function and lacks the …
iron homeostasis. Its isoform, hepcidin 20 (hep-20), has an unknown function and lacks the …
[HTML][HTML] Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice
M Hadziahmetovic, Y Song, P Ponnuru… - … & visual science, 2011 - jov.arvojournals.org
Purpose.: Iron dysregulation can cause retinal disease, yet retinal iron regulatory
mechanisms are incompletely understood. The peptide hormone hepcidin (Hepc) limits iron …
mechanisms are incompletely understood. The peptide hormone hepcidin (Hepc) limits iron …