[HTML][HTML] Tumor-induced inflammatory cytokines and the emerging diagnostic devices for cancer detection and prognosis

AER Kartikasari, CS Huertas, A Mitchell… - Frontiers in …, 2021 - frontiersin.org
Chronic inflammation generated by the tumor microenvironment is known to drive cancer
initiation, proliferation, progression, metastasis, and therapeutic resistance. The tumor …

The multifaceted role of iron in renal health and disease

RPL van Swelm, JFM Wetzels… - Nature Reviews …, 2020 - nature.com
Iron is an essential element that is indispensable for life. The delicate physiological body
iron balance is maintained by both systemic and cellular regulatory mechanisms. The iron …

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

DB Kell - BMC medical genomics, 2009 - Springer
Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

Hepcidin regulation by innate immune and infectious stimuli

AE Armitage, LA Eddowes, U Gileadi… - Blood, The Journal …, 2011 - ashpublications.org
Hepcidin controls the levels and distribution of iron, an element whose availability can
influence the outcome of infections. We investigated hepcidin regulation by infection …

Regulation of iron metabolism by hepcidin under conditions of inflammation

PJ Schmidt - Journal of Biological Chemistry, 2015 - ASBMB
Iron is a redox-active metal required as a cofactor in multiple metalloproteins essential for a
host of life processes. The metal is highly toxic when present in excess and must be strictly …

Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli

H Huang, M Constante, A Layoun… - Blood, The Journal of …, 2009 - ashpublications.org
Hepcidin, a key regulator of iron metabolism, is a small antimicrobial peptide produced by
the liver that regulates intestinal iron absorption and iron recycling by macrophages …

Hepcidin, the iron watcher

L Viatte, S Vaulont - Biochimie, 2009 - Elsevier
Hepcidin, a peptide hormone produced by the liver, constitutes the master regulator of iron
homeostasis in mammals allowing iron adaptation according to the body iron needs. In …

Current status of the measurement of blood hepcidin levels in chronic kidney disease

IC Macdougall, J Malyszko, RC Hider… - Clinical Journal of the …, 2010 - journals.lww.com
Hepcidin is a small defensin-like peptide produced in the liver in response to anemia,
hypoxia, or inflammation. In addition to its anti-microbial properties, it has also been found to …

Antimicrobial activity of human hepcidin 20 and 25 against clinically relevant bacterial strains: effect of copper and acidic pH

G Maisetta, R Petruzzelli, FL Brancatisano, S Esin… - Peptides, 2010 - Elsevier
Hepcidin 25 (hep-25) is a peptide primarily produced by human liver with a central role in
iron homeostasis. Its isoform, hepcidin 20 (hep-20), has an unknown function and lacks the …

[HTML][HTML] Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice

M Hadziahmetovic, Y Song, P Ponnuru… - … & visual science, 2011 - jov.arvojournals.org
Purpose.: Iron dysregulation can cause retinal disease, yet retinal iron regulatory
mechanisms are incompletely understood. The peptide hormone hepcidin (Hepc) limits iron …