Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions

R Bouillon, C Marcocci, G Carmeliet, D Bikle… - Endocrine …, 2019 - academic.oup.com
The etiology of endemic rickets was discovered a century ago. Vitamin D is the precursor of
25-hydroxyvitamin D and other metabolites, including 1, 25 (OH) 2D, the ligand for the …

Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects

S Christakos, P Dhawan, A Verstuyf… - Physiological …, 2016 - journals.physiology.org
1, 25-Dihydroxvitamin D3 [1, 25 (OH) 2D3] is the hormonally active form of vitamin D. The
genomic mechanism of 1, 25 (OH) 2D3 action involves the direct binding of the 1, 25 (OH) …

Non-linear Mendelian randomization analyses support a role for vitamin D deficiency in cardiovascular disease risk

A Zhou, JB Selvanayagam… - European Heart …, 2022 - academic.oup.com
Aims Low vitamin D status is associated with a higher risk for cardiovascular diseases
(CVDs). Although most existing linear Mendelian randomization (MR) studies reported a null …

The D-Health Trial: a randomised controlled trial of the effect of vitamin D on mortality

RE Neale, C Baxter, BD Romero… - The Lancet Diabetes & …, 2022 - thelancet.com
Background The effect of supplementing unscreened adults with vitamin D 3 on mortality is
unclear. We aimed to determine whether monthly doses of vitamin D 3 influenced mortality …

[HTML][HTML] Профилактика хронических неинфекционных заболеваний в Российской Федерации. Национальное руководство 2022

ОМ Драпкина, АВ Концевая, АМ Калинина… - Кардиоваскулярная …, 2022 - cyberleninka.ru
Члены Комитета экспертов подтвердили отсутствие финансовой поддержки/конфликта
интересов. В случае сообщения о наличии конфликта интересов, член (ы) Комитета …

[PDF][PDF] 2016 European Guidelines on cardiovascular disease prevention in clinical practice

MF Piepoli, AW Hoes, S Agewall… - Polish Heart …, 2016 - journals.viamedica.pl
2.3. 9. Wnioski................................................ 838 2.4. Inne markery ryzyka.......................................
. 840 2.4. 1. Wywiad rodzinny/(epi) genetyka............ 840 2.4. 1.1. Wywiad …

Effect of monthly high-dose vitamin D supplementation on cardiovascular disease in the vitamin D assessment study: a randomized clinical trial

R Scragg, AW Stewart, D Waayer, CMM Lawes… - JAMA …, 2017 - jamanetwork.com
Importance Cohort studies have reported increased incidence of cardiovascular disease
(CVD) among individuals with low vitamin D status. To date, randomized clinical trials of …

[HTML][HTML] Critical appraisal of large vitamin D randomized controlled trials

S Pilz, C Trummer, V Theiler-Schwetz, MR Grübler… - Nutrients, 2022 - mdpi.com
As a consequence of epidemiological studies showing significant associations of vitamin D
deficiency with a variety of adverse extra-skeletal clinical outcomes including cardiovascular …

[HTML][HTML] Vitamin D testing and treatment: a narrative review of current evidence

S Pilz, A Zittermann, C Trummer… - Endocrine …, 2019 - ec.bioscientifica.com
Vitamin D testing and treatment is a subject of controversial scientific discussions, and it is
challenging to navigate through the expanding vitamin D literature with heterogeneous and …

Association of serum 25-hydroxyvitamin D concentrations with all-cause and cause-specific mortality among individuals with diabetes

Z Wan, J Guo, A Pan, C Chen, L Liu, G Liu - Diabetes care, 2021 - Am Diabetes Assoc
OBJECTIVE The evidence regarding vitamin D status and mortality among people with
diabetes is scarce. This study aimed to examine the association of serum 25-hydroxyvitamin …