Opinion statement Colorectal cancer (CRC) is the third leading cancer diagnosed globally
and an important cause of cancer-related mortality. Of interest, while we have witnessed a …

Colorectal cancer (CRC) is one of the leading causes of cancer related mortality worldwide.
Although young-onset CRC raises the possibility of a hereditary component, hereditary CRC …

TGF-β signaling can be pro-tumorigenic or tumor suppressive. We investigated this duality in
pancreatic ductal adenocarcinoma (PDA), which, with other gastrointestinal cancers …

The gastrointestinal hamartomatous polyposis syndromes are rare, autosomal dominant
disorders associated with an increased risk of benign and malignant intestinal and …

Colorectal cancer (CRC) is the third most common cancer type and the second cause of
death worldwide. The advancement in understanding molecular pathways involved in CRC …

Colorectal cancer in the young adult population is of increasing incidence and concern.
Genetic predisposition and heritable syndromes contribute to this trend, but perhaps more …

Hereditary gastrointestinal (GI) cancer syndromes due to specific germline mutations are
characterized by an increased risk of GI tract malignancies, extra–GI tract cancers, and …

A large number of disorders may affect the oral cavity, including genetic diseases, infections,
cancers, blood diseases, skin diseases, endocrine and metabolic disorders, autoimmune …

In case of suspected hereditary predisposition to digestive cancers, next-generation
sequencing can analyze simultaneously several genes associated with an increased risk of …

Background: Digestive hamartomatous polyps are a rare entity. They may be sporadic
(solitary Peutz-Jeghers polyp or solitary juvenile polyp) or reveal genetic predisposition like …