Cell penetrating peptides: A versatile vector for co-delivery of drug and genes in cancer
MM Khan, N Filipczak, VP Torchilin - Journal of Controlled Release, 2021 - Elsevier
Biological barriers hamper the efficient delivery of drugs and genes to targeted sites. Cell
penetrating peptides (CPP) have the ability to rapidly internalize across biological …
penetrating peptides (CPP) have the ability to rapidly internalize across biological …
[HTML][HTML] Delivery systems for nucleic acids and proteins: Barriers, cell capture pathways and nanocarriers
Gene therapy has been used as a potential approach to address the diagnosis and
treatment of genetic diseases and inherited disorders. In this line, non-viral systems have …
treatment of genetic diseases and inherited disorders. In this line, non-viral systems have …
Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives
AFL Schneider, M Kithil, MC Cardoso, M Lehmann… - Nature Chemistry, 2021 - nature.com
Enabling the cellular delivery and cytosolic bioavailability of functional proteins constitutes a
major challenge for the life sciences. Here we demonstrate that thiol-reactive arginine-rich …
major challenge for the life sciences. Here we demonstrate that thiol-reactive arginine-rich …
[HTML][HTML] Cell-penetrating peptide sequence and modification dependent uptake and subcellular distribution of green florescent protein in different cell lines
Protein therapy holds great promise for treating a variety of diseases. To act on intracellular
targets, therapeutic proteins must cross the plasma membrane. This has previously been …
targets, therapeutic proteins must cross the plasma membrane. This has previously been …
Cellular deformations induced by conical silicon nanowire arrays facilitate gene delivery
Engineered cell–nanostructured interfaces generated by vertically aligned silicon nanowire
(SiNW) arrays have become a promising platform for orchestrating cell behavior, function …
(SiNW) arrays have become a promising platform for orchestrating cell behavior, function …
1988–2018: Thirty years of drug smuggling at the nano scale. Challenges and opportunities of cell-penetrating peptides in biomedical research
In 1988, two unrelated papers reported the discovery of peptide vectors with innate cell
translocation properties, setting the ground for a new area of research that over the years …
translocation properties, setting the ground for a new area of research that over the years …
Protamine-mediated efficient transcellular and transmucosal delivery of proteins
Proteins and peptides often require frequent needle-based administrations. Here, we report
a non-parenteral delivery method for proteins through physical mixing with protamine, an …
a non-parenteral delivery method for proteins through physical mixing with protamine, an …
Modulating tumor extracellular matrix by simultaneous inhibition of two cancer cell receptors
The extracellular matrix (ECM) is involved in fundamental cellular processes and
pathological progression of many diseases. While most research and current knowledge …
pathological progression of many diseases. While most research and current knowledge …
[HTML][HTML] Effect of the Lipid Landscape on the Efficacy of Cell-Penetrating Peptides
Every cell biological textbook teaches us that the main role of the plasma membrane is to
separate cells from their neighborhood to allow for a controlled composition of the …
separate cells from their neighborhood to allow for a controlled composition of the …
Bowl-shaped mesoporous polydopamine nanoparticles for size-dependent endocytosis into HeLa cells
S Acter, MLP Vidallon, S Crawford… - ACS Applied Nano …, 2021 - ACS Publications
A comprehensive study of cellular internalization mechanisms of nanoparticles is crucial to
optimize their drug delivery efficacy, as endocytosis pathways will likely determine their …
optimize their drug delivery efficacy, as endocytosis pathways will likely determine their …