Possession of the ε4 allele of apolipoprotein E (APOE) is the primary genetic risk factor for
the sporadic form of Alzheimer's disease (AD). While researchers have extensively …

Alzheimer disease (AD) originally meant a disorder of early-onset (EOAD;< 65 years of age)
and did not include older patients with “senile dementia.” In fact, the first patient reported …

Background: Population allele frequencies of apolipoprotein E (APOE) vary by geographic
region. The purpose of this study is to summarize and evaluate published estimates for the …

Some patients with early-onset Alzheimer's disease (AD) present with a distinct phenotype.
Typically, the first and most salient characteristic of AD is episodic memory impairment. A …

Patients with Alzheimer's disease (AD), the most prevalent neurodegenerative dementia, are
usually elderly; however,∼ 4–5% develop early-onset AD (EOAD) with onset before age 65 …

Background The objective of this study was to analyze factors influencing the risk and timing
of Alzheimer's disease (AD) in central Norway. The APOE ε4 allele is the only consistently …

Background: The Ε4 allele of apolipoprotein E (APOE) is associated with Alzheimer's
disease (AD). However, attributable risk due to APOE4 varies by region and by …

A growing body of research has examined the relationship between episodic memory
decline, the cognitive hallmark of Alzheimer's disease (AD), and the presence of …

Alzheimer's disease (AD) is a devastating neurodegenerative condition with significant
genetic heritability. Several genes have been implicated in the onset of AD with the …

BackgroundWe aimed to compare the rate of cognitive decline in patients with early and late
onset Alzheimer's disease (AD) and to investigate the potentially modifying influence of the …