Cycles in epilepsy

PJ Karoly, VR Rao, NM Gregg, GA Worrell… - Nature Reviews …, 2021 - nature.com
Epilepsy is among the most dynamic disorders in neurology. A canonical view holds that
seizures, the characteristic sign of epilepsy, occur at random, but, for centuries, humans …

Sleep medicine: Practice, challenges and new frontiers

L Parrino, P Halasz, A Szucs, RJ Thomas… - Frontiers in …, 2022 - frontiersin.org
Sleep medicine is an ambitious cross-disciplinary challenge, requiring the mutual
integration between complementary specialists in order to build a solid framework. Although …

Repeated hippocampal seizures lead to brain-wide reorganization of circuits and seizure propagation pathways

MK Choy, E Dadgar-Kiani, GO Cron, BA Duffy… - Neuron, 2022 - cell.com
Repeated seizure activity can lead to long-term changes in seizure dynamics and behavior.
However, resulting changes in brain-wide dynamics remain poorly understood. This is due …

Altered communication dynamics reflect cognitive deficits in temporal lobe epilepsy

M Girardi‐Schappo, F Fadaie, HM Lee, B Caldairou… - …, 2021 - Wiley Online Library
Objective Although temporal lobe epilepsy (TLE) is recognized as a system‐level disorder,
little work has investigated pathoconnectomics from a dynamic perspective. By leveraging …

Atypical functional connectome hierarchy impacts cognition in temporal lobe epilepsy

F Fadaie, HM Lee, B Caldairou, RS Gill, V Sziklas… - …, 2021 - Wiley Online Library
Objective Drug‐resistant temporal lobe epilepsy (TLE) is typically associated with
hippocampal pathology. However, widespread network alterations are increasingly …

Functional brain imaging in larval zebrafish for characterising the effects of seizurogenic compounds acting via a range of pharmacological mechanisms

MJ Winter, J Pinion, A Tochwin… - British Journal of …, 2021 - Wiley Online Library
Background and Purpose Functional brain imaging using genetically encoded Ca2+
sensors in larval zebrafish is being developed for studying seizures and epilepsy as a more …

Networks in temporal lobe epilepsy

KAG Otárula, S Schuele - Neurosurgery Clinics, 2020 - neurosurgery.theclinics.com
The goal of resective epilepsy surgery is to remove the minimal area of cortex to produce
seizure freedom, known as the epileptogenic zone (EZ). 1 Temporal lobe epilepsy (TLE) is …

[HTML][HTML] Altered structural connectome in non-lesional newly diagnosed focal epilepsy: Relation to pharmacoresistance

BAK Kreilkamp, A McKavanagh, B Alonazi, L Bryant… - NeuroImage: Clinical, 2021 - Elsevier
Despite an expanding literature on brain alterations in patients with longstanding epilepsy,
few neuroimaging studies investigate patients with newly diagnosed focal epilepsy (NDfE) …

Brain network dynamics codify heterogeneity in seizure evolution

N Rungratsameetaweemana, C Lainscsek… - Brain …, 2022 - academic.oup.com
Dynamic functional brain connectivity facilitates adaptive cognition and behaviour. Abnormal
alterations within such connectivity could result in disrupted functions observed across …

Etiology‐specific response to antiseizure medication in focal epilepsy

JI Doerrfuss, AB Kowski, M Holtkamp - Epilepsia, 2021 - Wiley Online Library
Objective In focal epilepsy, data on the etiology‐specific response to antiseizure medication
(ASM) are surprisingly sparse. In this study, we sought to reappraise whether seizure …