Alphaviruses cause severe human illnesses including persistent arthritis and fatal
encephalitis. As alphavirus entry into target cells is the first step in infection, intensive …

The interferon-inducible transmembrane protein (IFITM) family inhibits a growing number of
pathogenic viruses, among them influenza A virus, dengue virus, hepatitis C virus, and …

Influenza viruses exploit host cell machinery to replicate, resulting in epidemics of
respiratory illness. In turn, the host expresses antiviral restriction factors to defend against …

The process of entry into a host cell is a key step in the life cycle of most viruses. In recent
years, there has been a significant increase in our understanding of the routes and …

Background Dengue is currently the most important arthropod-borne viral disease of
humans. Recent work has shown dengue virus displays limited replication in its primary …

The study of enveloped animal viruses has greatly advanced our understanding of the
general properties of membrane fusion and of the specific pathways that viruses use to infect …

Flaviviruses are small spherical virus particles covered by a dense icosahedral array of
envelope (E) proteins that mediate virus attachment to cells and the fusion of viral and …

Alphaviruses are enveloped positive sense RNA viruses and include serious human
pathogens, such as the encephalitic alphaviruses and Chikungunya virus. Alphaviruses are …

Viral pathogens present many challenges to organisms, driving the evolution of a myriad of
antiviral strategies to combat infections. A wide variety of viruses infect invertebrates …

Assembly of virus capsids and surface proteins must be regulated to ensure that the
resulting complex is an infectious virion. In this review, we examine assembly of virus …