Potential toxic effects of glyphosate and its commercial formulations below regulatory limits

R Mesnage, N Defarge, JS De Vendômois… - Food and Chemical …, 2015 - Elsevier
Abstract Glyphosate-based herbicides (GlyBH), including Roundup, are the most widely
used pesticides worldwide. Their uses have increased exponentially since their introduction …

[HTML][HTML] Insight into the confusion over surfactant co-formulants in glyphosate-based herbicides

R Mesnage, C Benbrook, MN Antoniou - Food and Chemical Toxicology, 2019 - Elsevier
Glyphosate is the active ingredient in glyphosate-based herbicides (GBHs). Other chemicals
in GBHs are presumed as inert by regulatory authorities and are largely ignored in pesticide …

Ethoxylated adjuvants of glyphosate-based herbicides are active principles of human cell toxicity

R Mesnage, B Bernay, GE Séralini - Toxicology, 2013 - Elsevier
Pesticides are always used in formulations as mixtures of an active principle with adjuvants.
Glyphosate, the active ingredient of the major pesticide in the world, is an herbicide …

[HTML][HTML] Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies

A Samsel, S Seneff - Surgical neurology international, 2015 - ncbi.nlm.nih.gov
Manganese (Mn) is an often overlooked but important nutrient, required in small amounts for
multiple essential functions in the body. A recent study on cows fed genetically modified …

Co-formulants in glyphosate-based herbicides disrupt aromatase activity in human cells below toxic levels

N Defarge, E Takács, VL Lozano, R Mesnage… - International Journal of …, 2016 - mdpi.com
Pesticide formulations contain declared active ingredients and co-formulants presented as
inert and confidential compounds. We tested the endocrine disruption of co-formulants in six …

[HTML][HTML] Roundup disrupts male reproductive functions by triggering calcium-mediated cell death in rat testis and Sertoli cells

VLLO Cavalli, D Cattani, CEH Rieg, P Pierozan… - Free Radical Biology …, 2013 - Elsevier
Glyphosate is the primary active constituent of the commercial pesticide Roundup. The
present results show that acute Roundup exposure at low doses (36 ppm, 0.036 g/L) for 30 …

[HTML][HTML] Mapping the key characteristics of carcinogens for glyphosate and its formulations: a systematic review

I Rana, PK Nguyen, G Rigutto, A Louie, J Lee… - Chemosphere, 2023 - Elsevier
Glyphosate was classified as a probable human carcinogen by the International Agency for
Research on Cancer (IARC) partially due to strong mechanistic evidence in 2015. Since …

The role of inflammation in cadmium nephrotoxicity: NF-κB comes into view

EHM Hassanein, WR Mohamed, OS Ahmed… - Life Sciences, 2022 - Elsevier
Kidney diseases are major health problem and understanding the underlined mechanisms
that lead to kidney diseases are critical research points with a marked potential impact on …

A comprehensive analysis of the animal carcinogenicity data for glyphosate from chronic exposure rodent carcinogenicity studies

CJ Portier - Environmental Health, 2020 - Springer
Since the introduction of glyphosate-tolerant genetically-modified plants, the global use of
glyphosate has increased dramatically making it the most widely used pesticide on the …

Evaluation of biochemical, hematological and oxidative parameters in mice exposed to the herbicide glyphosate-Roundup®

R Jasper, GO Locatelli, C Pilati… - Interdisciplinary toxicology, 2012 - sciendo.com
We evaluated the toxicity of hepatic, hematological, and oxidative effects of glyphosate-
Roundup® on male and female albino Swiss mice. The animals were treated orally with …