The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

Diabetes mellitus is a debilitating and often life-threatening disease with increasing
incidence in rural populations throughout the world. A scientific investigation of traditional …

A member of the inwardly rectifying potassium channel family was cloned here. The
channel, called BIR (Kir6. 2), was expressed in large amounts in rat pancreatic islets and …

1. A TP-Regulated K+-Channels (KA TP Channels)(a) Single-channel conductance and
voltage dependence (b) Permeability and selectivity (c) Kinetics (d) Effects of. 4 TP (i) …

The properties and roles of ATP-sensitive (KATP) and inwardly rectifying (KIR) potassium
channels are reviewed. Potassium channels regulate the membrane potential of smooth …

Molecular Biology of Adenosine Triphosphate-Sensitive Potassium Channels* | Endocrine
Reviews | Oxford Academic Skip to Main Content Advertisement Oxford Academic Journals …

H2S is an important gasotransmitter, generated in mammalian cells from l‐cysteine
metabolism. As it stimulates KATP channels in vascular smooth muscle cells, H2S may also …

ATP-sensitive potassium (KATP) channels are present in many tissues, including pancreatic
islet cells, heart, skeletal muscle, vascular smooth muscle, and brain, in which they couple …

Glucose stimulation of insulin release involves closure of ATP-sensitive K+ channels,
depolarization, and Ca2+ influx in B cells. Mouse islets were used to investigate whether …

ATP-sensitive K+ (KATP) channels regulate many cellular functions by linking cell
metabolism to membrane potential. We have generated KATP channel-deficient mice by …