Lassa fever—the road ahead
RF Garry - Nature Reviews Microbiology, 2023 - nature.com
Lassa virus (LASV) is endemic in the rodent populations of Sierra Leone, Nigeria and other
countries in West Africa. Spillover to humans occurs frequently and results in Lassa fever, a …
countries in West Africa. Spillover to humans occurs frequently and results in Lassa fever, a …
Pathogenesis of Lassa fever
NE Yun, DH Walker - Viruses, 2012 - mdpi.com
Lassa virus, an Old World arenavirus (family Arenaviridae), is the etiological agent of Lassa
fever, a severe human disease that is reported in more than 100,000 patients annually in the …
fever, a severe human disease that is reported in more than 100,000 patients annually in the …
A recombinant VSV-vectored vaccine rapidly protects nonhuman primates against heterologous lethal Lassa fever
Lassa virus (LASV) is recognized by the World Health Organization as one of the top five
pathogens likely to cause a severe outbreak. A recent unprecedented resurgence of LASV …
pathogens likely to cause a severe outbreak. A recent unprecedented resurgence of LASV …
Arenavirus glycan shield promotes neutralizing antibody evasion and protracted infection
R Sommerstein, L Flatz, MM Remy, P Malinge… - PLoS …, 2015 - journals.plos.org
Arenaviruses such as Lassa virus (LASV) can cause severe hemorrhagic fever in humans.
As a major impediment to vaccine development, delayed and weak neutralizing antibody …
As a major impediment to vaccine development, delayed and weak neutralizing antibody …
Non-neutralizing antibodies elicited by recombinant Lassa–Rabies vaccine are critical for protection against Lassa fever
T Abreu-Mota, KR Hagen, K Cooper… - Nature …, 2018 - nature.com
Lassa fever (LF), caused by Lassa virus (LASV), is a viral hemorrhagic fever for which no
approved vaccine or potent antiviral treatment is available. LF is a WHO priority disease and …
approved vaccine or potent antiviral treatment is available. LF is a WHO priority disease and …
Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice
H Frebel, V Nindl, RA Schuepbach… - Journal of Experimental …, 2012 - rupress.org
The inhibitory programmed death 1 (PD-1)–programmed death ligand 1 (PD-L1) pathway
contributes to the functional down-regulation of T cell responses during persistent systemic …
contributes to the functional down-regulation of T cell responses during persistent systemic …
A human monoclonal antibody combination rescues nonhuman primates from advanced disease caused by the major lineages of Lassa virus
RW Cross, ML Heinrich, KA Fenton… - Proceedings of the …, 2023 - National Acad Sciences
There are no approved treatments for Lassa fever (LF), which is responsible for thousands of
deaths each year in West Africa. A major challenge in developing effective medical …
deaths each year in West Africa. A major challenge in developing effective medical …
Ribavirin for treating Lassa fever: A systematic review of pre-clinical studies and implications for human dosing
AP Salam, A Duvignaud, M Jaspard… - PLoS Neglected …, 2022 - journals.plos.org
Ribavirin is currently the standard of care for treating Lassa fever. However, the human
clinical trial data supporting its use suffer from several serious flaws that render the results …
clinical trial data supporting its use suffer from several serious flaws that render the results …
Pathogenicity and virulence mechanisms of Lassa virus and its animal modeling, diagnostic, prophylactic, and therapeutic developments
HL Murphy, H Ly - Virulence, 2021 - Taylor & Francis
Lassa fever (LF) is a deadly viral hemorrhagic disease that is endemic to West Africa. The
causative agent of LF is Lassa virus (LASV), which causes approximately 300,000 infections …
causative agent of LF is Lassa virus (LASV), which causes approximately 300,000 infections …
Effective oral favipiravir (T-705) therapy initiated after the onset of clinical disease in a model of arenavirus hemorrhagic Fever
M Mendenhall, A Russell, DF Smee… - PLoS neglected …, 2011 - journals.plos.org
Background Lassa and Junín viruses are the most prominent members of the Arenaviridae
family of viruses that cause viral hemorrhagic fever syndromes Lassa fever and Argentine …
family of viruses that cause viral hemorrhagic fever syndromes Lassa fever and Argentine …