Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide. Motor deficits usually associated with PD correlate with dopaminergic axonal …

Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

Background Iron content is increased in the substantia nigra of persons with Parkinson's
disease and may contribute to the pathophysiology of the disorder. Early research suggests …

Background Osteoarthritis (OA) is the most common joint disease and is the leading cause
of chronic disability among older people. Chondrocyte death and extracellular matrix (ECM) …

Ferroptosis, triggered by discoordination of iron, thiols and lipids, leads to the accumulation
of 15-hydroperoxy (Hp)-arachidonoyl-phosphatidylethanolamine (15-HpETE-PE), generated …

Ferroptosis, a new form of regulated cell death triggered by the iron-dependent peroxidation
of phospholipids, is associated with cellular metabolism, redox homeostasis, and various …

Background: The protective effect of quercetin on nonalcoholic fatty liver disease (NAFLD)
has been reported, but its mechanism remains poorly understood. Recently, quercetin was …

Ferroptosis, a novel form of regulated cell death, is caused by accumulation of lipid
peroxides and excessive iron deposition. This process has been linked to the death of …

Osteoarthritis (OA) is a multifactorial and increasingly prevalent degenerative disease that
affects the whole joint. The pathogenesis of OA is poorly understood and there is a lack of …

The selenoprotein glutathione peroxidase 4 (GPX4) is one of the main antioxidant mediators
in the human body. Its central function involves the reduction of complex hydroperoxides into …