Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction, and chronic
pruritus. As the anti-interleukin-4 (IL-4) receptor α antibody dupilumab improves all three …

The cutaneous immune response is important for the regulation of skin aging well as for the
development of immune-mediated skin diseases. Aging of the human skin undergoes …

Background Although atopic dermatitis (AD) often starts in early childhood, detailed tissue
profiling of early-onset AD in children is lacking, hindering therapeutic development for this …

Atopic dermatitis is a common pruritic skin disease in which barrier dysfunction and
cutaneous inflammation contribute to pathogenesis. Mechanisms underlying the associated …

Atopic dermatitis (AD) is one of the most common chronic, inflammatory skin disorders with a
complex etiology and a broad spectrum of clinical phenotypes. Despite its high prevalence …

Atopic dermatitis, which is related to dermatologic disorders and is associated with skin
barrier dysfunction, represents an epidemic problem demanding effective therapeutic …

Non-invasive ventilation is commonly used for respiratory support. However, in some cases,
mask application can cause pressure ulcers to specific features of the face, resulting in pain …

The skin is a formidable diffusion barrier that restricts passive diffusion to small (< 500 Da)
lipophilic molecules. Methods used to permeabilize this barrier for the purpose of drug …

Immunosenescence is a complex multifactorial phenomenon consisting of wide-ranging
remodeling of the immune system during the life span, resulting in an age-related qualitative …

Human skin is composed of three layers: the epidermis, the dermis, and the hypodermis.
The epidermis has four major cell layers made up of keratinocytes in varying stages of …