Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite

DJ Park, AK Lukens, DE Neafsey… - Proceedings of the …, 2012 - National Acad Sciences
Through rapid genetic adaptation and natural selection, the Plasmodium falciparum parasite—
the deadliest of those that cause malaria—is able to develop resistance to antimalarial …

[HTML][HTML] Nuclease activity of Plasmodium falciparum Alba family protein PfAlba3

C Banerjee, S Nag, M Goyal, D Saha, AA Siddiqui… - Cell Reports, 2023 - cell.com
Plasmodium falciparum Alba domain-containing protein Alba3 (PfAlba3) is ubiquitously
expressed in intra-erythrocytic stages of Plasmodium falciparum, but the function of this …

Unraveling the importance of the malaria parasite helicases

R Tuteja - The FEBS Journal, 2017 - Wiley Online Library
Malaria is a human parasitic disease caused by infection from Plasmodium species,
particularly Plasmodium falciparum. Each year millions of people are infected with malaria …

Genome Wide In silico Analysis of the Mismatch Repair Components of Plasmodium falciparum and Their Comparison with Human Host

M Tarique, M Ahmad, M Chauhan… - Frontiers in microbiology, 2017 - frontiersin.org
Malaria a major parasitic infection globally particularly in tropical and sub-tropical regions of
the world is responsible for about 198 million cases and estimated deaths due to this …

A novel Pfs38 protein complex on the surface of Plasmodium falciparum blood-stage merozoites

G Paul, A Deshmukh, I Kaur, S Rathore, S Dabral… - Malaria journal, 2017 - Springer
Abstract Background The Plasmodium genome encodes for a number of 6-Cys proteins that
contain a module of six cysteine residues forming three intramolecular disulphide bonds …

Plasmodium falciparum UvrD Helicase Translocates in 3′ to 5′ Direction, Colocalizes with MLH and Modulates Its Activity through Physical Interaction

M Ahmad, A Ansari, M Tarique, AT Satsangi, R Tuteja - PLoS One, 2012 - journals.plos.org
Malaria is a global disease and a major health problem. The control of malaria is a daunting
task due to the increasing drug resistance. Therefore, there is an urgent need to identify and …

Plasmodium falciparum Bloom homologue, a nucleocytoplasmic protein, translocates in 3′ to 5′ direction and is essential for parasite growth

F Rahman, M Tarique, R Tuteja - … et Biophysica Acta (BBA)-Proteins and …, 2016 - Elsevier
Malaria caused by Plasmodium, particularly Plasmodium falciparum, is the most serious and
widespread parasitic disease of humans. RecQ helicase family members are essential in …

Novel RuvB nuclear ATPase is specific to intraerythrocytic mitosis during schizogony of Plasmodium falciparum

M Ahmad, S Singh, F Afrin, R Tuteja - Molecular and biochemical …, 2012 - Elsevier
RuvB protein belongs to AAA+ family of enzymes involved in diverse cellular activities. In
addition to the annotated two RuvB proteins in Plasmodium falciparum database, we report …

Plasmodium Ape1 is a multifunctional enzyme in mitochondrial base excision repair and is required for efficient transition from liver to blood stage infection

N Verma, H Shukla, A Tiwari, S Mishra, S Habib - DNA repair, 2021 - Elsevier
The malaria parasite has a single mitochondrion which carries multiple tandem repeats of its
6 kb genome encoding three proteins of the electron transport chain. There is little …

Plasmodium falciparum Apn1 homolog is a mitochondrial base excision repair protein with restricted enzymatic functions

A Tiwari, J Kuldeep, MI Siddiqi, S Habib - The FEBS Journal, 2020 - Wiley Online Library
The malaria parasite carries two organelles, the apicoplast and mitochondrion, whose DNA
genomes must be maintained for optimal function and parasite survival under genotoxic …