Inflammation is usually considered as harmful; however, it is also necessary for tissue
recovery after injury. Macrophages exert immune and nonimmune functions throughout this …

The complement system is deeply embedded in our physiology and immunity. Complement
activation generates a multitude of molecules that converge simultaneously on the …

Here, using single-cell RNA sequencing, we examine the stromal compartment in murine
melanoma and draining lymph nodes (LNs) at points across tumor development, providing …

Clearance of cellular debris is required to maintain the homeostasis of multicellular
organisms. It is intrinsic to processes such as tissue growth and remodeling, regeneration …

Mammalian phagocytes can phagocytose (ie eat) other mammalian cells in the body if they
display certain signals, and this phagocytosis plays fundamental roles in development, cell …

Skeletal muscle injuries occur frequently in daily life and exercise. Understanding the
mechanisms of regeneration is critical for accelerating the repair and regeneration of …

Skeletal muscle regeneration involves coordinated interactions between different cell types.
Injection of platelet-rich plasma is circumstantially considered an aid to muscle repair but …

The complement system is an essential part of innate immunity, typically conferring
protection via eliminating pathogens and accumulating debris. However, the defensive …

Emerging evidence suggests that the signalling of the Receptor for Advanced Glycation End
products (RAGE) is critical for skeletal muscle physiology controlling both the activity of …

The adult skeletal muscle fully regenerates after injury thanks to the properties of muscle
stem cells that follow the adult myogenic program to replace damaged myofibers. Muscle …