Flow chemistry studies can sometimes be difficult to reproduce. In this article we provide
guidance to scientists for experimental details that should be considered as part of any …

Privileged scaffolds as starting points toward biologically active molecules represent a
neuralgic point in drug discovery. The ability of synthetic chemists concerned with their …

Nitroarenes are the entry point for the production of most nitrogen‐containing aromatic
compounds. Thus, any transformation that leads directly from them to the final product allows …

The reductive cyclization reaction of o-nitrostyrenes to generate indoles has been
investigated for three decades using CO as a cheap reducing agent, but it remains an …

Indole is the most frequently found heterocyclic core structures in pharmaceuticals, natural
products, agrochemicals, dyes and fragrances. For about 150 years, chemists were …

Indole derivatives are among the most useful and interesting heterocycles employed in drug
discovery and medicinal chemistry. In addition, flow chemistry and flow technology are …

Alkyl and aryl formate esters were evaluated as CO sources in the Pd‐and Pd/Ru‐catalyzed
reductive cyclization of 2‐nitrostyrenes to give indoles. Whereas the use of alkyl formates …

Flow Chemistry is a revolutionary field in Organic Chemistry. By changing the conventional
methods and apparatus applied in the chemical synthesis, flow chemistry emerges as a …

A continuous-flow Pd-catalyzed oxidative carbonylation protocol utilizing CO and O2 gas for
the synthesis of carbonylated heterocycles is described. The optimization of temperature …

A continuous photochemical process is presented that renders a series of quinoline
products via an alkene isomerization and cyclocondensation cascade. It is demonstrated …