The nuclear receptors REV-ERB (consisting of REV-ERBα and REV-ERBβ) and retinoic acid
receptor-related orphan receptors (RORs; consisting of RORα, RORβ and RORγ) are …

The last few years have witnessed a rapid increase in our knowledge of the retinoid-related
orphan receptors RORα,-β, and-γ (NR1F1-3), their mechanism of action, physiological …

The circadian clock programs daily rhythms and coordinates multiple behavioral and
physiological processes, including activity, sleep, feeding, and fuel homeostasis. Recent …

Obesity has become a serious public health problem and a major risk factor for the
development of illnesses, such as insulin resistance and hypertension. Human homeostatic …

The mammalian clock regulates major aspects of energy metabolism, including glucose and
lipid homeostasis and mitochondrial oxidative metabolism,. The biochemical basis for …

Melatonin, the main secretory product of the pineal gland, is known to collaborate against
oxidative stress within cells, but its mechanism of action in terms of stimulating antioxidant …

The suprachiasmatic nucleus (SCN) in the mammalian hypothalamus functions as an
endogenous pacemaker that generates and maintains circadian rhythms throughout the …

The mammalian circadian clockwork is composed of a core PER/CRY feedback loop and
additional interlocking loops. In particular, the ROR/REV/Bmal1 loop, consisting of ROR …

Circadian rhythms are approximate 24-h behavioral and physiological cycles that function to
prepare an organism for daily environmental changes. The basic clock mechanism is a …

The master clock located in the suprachiasmatic nuclei (SCN) of the anterior hypothalamus
regulates circadian rhythms in mammals. The clock is an intracellular, transcriptional …