Pseudomonas aeruginosa is an opportunistic human pathogen causing devastating acute
and chronic infections in individuals with compromised immune systems. Its highly notorious …

In human pathophysiology, the clash between microbial infection and host immunity
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …

The pulmonary microbial community, described only a few years ago, forms a discreet part
of the human host microbiota. The airway microbiota has been found to be substantially …

The respiratory tract is a complex organ system that is responsible for the exchange of
oxygen and carbon dioxide. The human respiratory tract spans from the nostrils to the lung …

Although the notion that “the normal lung is free from bacteria” remains common in
textbooks, it is virtually always stated without citation or argument. The lungs are constantly …

Rationale: The lung microbiome is spatially heterogeneous in advanced airway diseases,
but whether it varies spatially in health is unknown. We postulated that the primary …

Background The human lung tissue microbiota remains largely uncharacterized, although a
number of studies based on airway samples suggest the existence of a viable human lung …

The airways of patients with cystic fibrosis (CF) are nearly always infected with many
different microorganisms. This environment offers warm, humid and nutrient-rich conditions …

Antivirulence drugs are a new type of therapeutic drug that target virulence factors,
potentially revitalising the drug-development pipeline with new targets. As antivirulence …

Novel culture-independent techniques have recently demonstrated that the lower respiratory
tract, historically considered sterile in health, contains diverse communities of microbes: the …