Osteocytes, former osteoblasts encapsulated by mineralized bone matrix, are far from being
passive and metabolically inactive bone cells. Instead, osteocytes are multifunctional and …

We review the characteristics of osteoblast differentiation and bone matrix synthesis. Bone in
air breathing vertebrates is a specialized tissue that developmentally replaces simpler solid …

The Bioarchaeology of Metabolic Bone Disease, Second Edition is a comprehensive source
dedicated to better understanding this group of conditions that have significant …

The bone marrow has been widely recognised to host a unique microenvironment that
facilitates tumour colonisation. Bone metastasis frequently occurs in the late stages of …

Multiple myeloma (MM) causes lytic bone lesions due to increased bone resorption and
concomitant marked suppression of bone formation. Sclerostin (Scl), an osteocyte-derived …

Osteocytes integrate the responses of bone to mechanical and hormonal stimuli by poorly
understood mechanisms. We report here that mice with conditional deletion of the …

Interest in space exploration has seen substantial growth following recent launch and
operation of modern space technologies. In particular, the possibility of travel beyond low …

Abstract Purpose of Review Osteocytes are the main mechanosensitive cells in bone.
Integrin-based adhesions have been shown to facilitate mechanotransduction, and therefore …

Abstract Purpose of Review Osteocytes comprise> 95% of the cellular component in bone
tissue and produce a wide range of cytokines and cellular signaling molecules in response …

Advances in the last decade have established the osteocyte, the most abundant cell in bone,
as a dynamic and multifunctional cell capable of controlling bone homeostasis by regulating …