Reprogramming of lipid metabolism is a newly recognized hallmark of malignancy.
Increased lipid uptake, storage and lipogenesis occur in a variety of cancers and contribute …

Scap is a polytopic membrane protein that functions as a molecular machine to control the
cholesterol content of membranes in mammalian cells. In the 21 years since our laboratory …

Lipids form a diverse group of water‐insoluble molecules that include triacylglycerides,
phosphoglycerides, sterols and sphingolipids. They play several important roles at cellular …

Cholesterol is an essential component of animal cell membranes, and its concentration is
tightly controlled by a feedback system that operates at transcriptional and …

Tumorigenesis is associated with elevated glucose and glutamine consumption, but how
cancer cells can sense their levels to activate lipid synthesis is unknown. Here, we reveal …

Secretory proteins are transported to the Golgi complex in vesicles that bud from the
endoplasmic reticulum. The cytoplasmic coat protein complex II (COPII) is responsible for …

Cholesterol is an essential component of mammalian cell membranes and is required for
proper membrane permeability, fluidity, organelle identity, and protein function. Cells …

Cholesterol biosynthesis is among the most intensely regulated processes in biology.
Synthetic rates vary over hundreds of fold depending on the availability of an external …

In mammals, intracellular levels of cholesterol and fatty acids are controlled through a
feedback regulatory system mediated by a family of transcription factors called sterol …

The sterol regulatory element binding proteins (SREBPs) are transcription factors that
govern cholesterol and fatty acid metabolism. We recently identified SPRING as a post …