Cardiopulmonary exercise testing (CPET) is a method for evaluating pulmonary and
cardiocirculatory abnormalities, dyspnea, and exercise tolerance in healthy individuals and …

Patients with heart failure with preserved ejection fraction (HFpEF) universally complain of
exercise intolerance and dyspnoea as key clinical correlates. Cardiac as well as …

The heart and lungs are anatomically coupled through the pulmonary circulation and coexist
within the sealed thoracic cavity, making the function of these systems highly …

Increased ventilation relative to metabolic demands, indicating alveolar hyperventilation
and/or increased physiological dead space (excess ventilation), is a key cause of exertional …

Heart failure with preserved ejection fraction (HFpEF) patients have an increased ventilatory
demand. Whether their ventilatory capacity can meet this increased demand is unknown …

Heart failure with reduced ejection fraction (HF) is a common and disabling comorbidity of
chronic obstructive pulmonary disease (COPD). 1 The prevalence of comorbid COPD-HF is …

There is well established evidence that the minute ventilation (V′ E)/carbon dioxide output
(V′ CO 2) relationship is relevant to a number of patient-related outcomes in COPD. In most …

Moderate-to-severe traumatic brain injury (TBI) is a chronic health condition with multi-
systemic effects. Survivors face significant long-term functional limitations, including physical …

New Findings What is the central question of this study? The goal of this study was to
investigate the effect of alterations in tidal volume and alveolar volume on the elevated …

In chronic heart failure, minute ventilation (V′ E) for a given carbon dioxide production (V′
CO 2) might be abnormally high during exercise due to increased dead space ventilation …