Structure and function of hexameric helicases
SS Patel, KM Picha - Annual review of biochemistry, 2000 - annualreviews.org
▪ Abstract Helicases are motor proteins that couple the hydrolysis of nucleoside triphosphate
(NTPase) to nucleic acid unwinding. The hexameric helicases have a characteristic ring …
(NTPase) to nucleic acid unwinding. The hexameric helicases have a characteristic ring …
Structure of hexameric DnaB helicase and its complex with a domain of DnaG primase
S Bailey, WK Eliason, TA Steitz - Science, 2007 - science.org
The complex between the DnaB helicase and the DnaG primase unwinds duplex DNA at the
eubacterial replication fork and synthesizes the Okazaki RNA primers. The crystal structures …
eubacterial replication fork and synthesizes the Okazaki RNA primers. The crystal structures …
[HTML][HTML] The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus
Bananins are a class of antiviral compounds with a unique structural signature incorporating
a trioxa-adamantane moiety covalently bound to a pyridoxal derivative. Six members of this …
a trioxa-adamantane moiety covalently bound to a pyridoxal derivative. Six members of this …
The bacterial replicative helicase DnaB evolved from a RecA duplication
The RecA/Rad51/DCM1 family of ATP-dependent recombinases plays a crucial role in
genetic recombination and double-stranded DNA break repair in Archaea, Bacteria, and …
genetic recombination and double-stranded DNA break repair in Archaea, Bacteria, and …
[HTML][HTML] Replisome assembly at bacterial chromosomes and iteron plasmids
KE Wegrzyn, M Gross, U Uciechowska… - Frontiers in molecular …, 2016 - frontiersin.org
The proper initiation and occurrence of DNA synthesis depends on the formation and
rearrangements of nucleoprotein complexes within the origin of DNA replication. In this …
rearrangements of nucleoprotein complexes within the origin of DNA replication. In this …
Mapping Protein−Protein Interactions within a Stable Complex of DNA Primase and DnaB Helicase from Bacillus stearothermophilus
For the first time, we demonstrate directly a stable complex between a bacterial DnaG
(primase) and DnaB (helicase). Utilizing fragments of both proteins, we are able to dissect …
(primase) and DnaB (helicase). Utilizing fragments of both proteins, we are able to dissect …
[HTML][HTML] Nucleotide and partner-protein control of bacterial replicative helicase structure and function
MS Strycharska, E Arias-Palomo, AY Lyubimov… - Molecular cell, 2013 - cell.com
Cellular replication forks are powered by ring-shaped, hexameric helicases that encircle and
unwind DNA. To better understand the molecular mechanisms and control of these …
unwind DNA. To better understand the molecular mechanisms and control of these …
[HTML][HTML] Crystal structure of the N-terminal domain of the DnaB hexameric helicase
Abstract Background: The hexameric helicase DnaB unwinds the DNA duplex at the
Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both …
Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both …
DnaB helicase stimulates primer synthesis activity on short oligonucleotide templates
SK Johnson, S Bhattacharyya, MA Griep - Biochemistry, 2000 - ACS Publications
DnaB helicase stimulated the second-order RNA primer synthesis activity of primase by over
5000-fold on DNA templates that were 23 nucleotides long. This template length is the same …
5000-fold on DNA templates that were 23 nucleotides long. This template length is the same …
[HTML][HTML] The DnaB· DnaC complex: a structure based on dimers assembled around an occluded channel
M Bárcena, T Ruiz, LE Donate, SE Brown… - The EMBO …, 2001 - embopress.org
Replicative helicases are motor proteins that unwind DNA at replication forks. Escherichia
coli DnaB is the best characterized member of this family of enzymes. We present the 26 Å …
coli DnaB is the best characterized member of this family of enzymes. We present the 26 Å …